I17RE_MOUSE
ID I17RE_MOUSE Reviewed; 637 AA.
AC Q8BH06; Q3I5F0; Q6NSU9; Q8C5D0; Q8K4C1; Q8R335;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Interleukin-17 receptor E;
DE Short=IL-17 receptor E;
DE Short=IL-17RE;
DE Flags: Precursor;
GN Name=Il17re;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), FUNCTION, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=16310341; DOI=10.1016/j.cellsig.2005.10.010;
RA Li T.-S., Li X.-N., Chang Z.-J., Fu X.-Y., Liu L.;
RT "Identification and functional characterization of a novel interleukin 17
RT receptor: a possible mitogenic activation through ras/mitogen-activated
RT protein kinase signaling pathway.";
RL Cell. Signal. 18:1287-1298(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Gilbert J.M., Gorman D.M.;
RT "Identification of novel IL-17 related receptors.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
RC STRAIN=C57BL/6J;
RC TISSUE=Adipose tissue, Colon, Corpora quadrigemina, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
RC STRAIN=C57BL/6J, and Czech II;
RC TISSUE=Mammary tumor, and Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, IDENTIFICATION AS IL17C RECEPTOR, INTERACTION WITH IL17RA, TISSUE
RP SPECIFICITY, AND INDUCTION.
RX PubMed=21982598; DOI=10.1016/j.immuni.2011.09.010;
RA Chang S.H., Reynolds J.M., Pappu B.P., Chen G., Martinez G.J., Dong C.;
RT "Interleukin-17C promotes Th17 cell responses and autoimmune disease via
RT interleukin-17 receptor E.";
RL Immunity 35:611-621(2011).
RN [6]
RP FUNCTION, IDENTIFICATION AS IL17C RECEPTOR, INTERACTION WITH IL17RA, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=21993849; DOI=10.1038/ni.2155;
RA Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.;
RT "IL-17RE is the functional receptor for IL-17C and mediates mucosal
RT immunity to infection with intestinal pathogens.";
RL Nat. Immunol. 12:1151-1158(2011).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=21993848; DOI=10.1038/ni.2156;
RA Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J.,
RA Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M.,
RA Caplazi P., Diehl L., de Voss J., Balazs M., Gonzalez L. Jr., Singh H.,
RA Ouyang W., Pappu R.;
RT "IL-17C regulates the innate immune function of epithelial cells in an
RT autocrine manner.";
RL Nat. Immunol. 12:1159-1166(2011).
CC -!- FUNCTION: Specific functional receptor for IL17C, signaling through the
CC NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling.
CC Crucial regulator in innate immunity to bacterial pathogens, such as
CC Citrobacter rodentium. Isoform 4 and isoform 5 may be either
CC cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3
CC may act as soluble decoy receptors. {ECO:0000269|PubMed:16310341,
CC ECO:0000269|PubMed:21982598, ECO:0000269|PubMed:21993849}.
CC -!- SUBUNIT: Forms heterodimers with IL17RA; the heterodimer binds IL17C.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I
CC membrane protein.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1; Synonyms=IL-17RE1, IL17RE-S;
CC IsoId=Q8BH06-1; Sequence=Displayed;
CC Name=2; Synonyms=IL-17RE2;
CC IsoId=Q8BH06-2; Sequence=VSP_029200;
CC Name=3; Synonyms=IL-17RE3;
CC IsoId=Q8BH06-3; Sequence=VSP_029199;
CC Name=4; Synonyms=IL-17RE4, IL-17RE5, IL17RE-S;
CC IsoId=Q8BH06-4; Sequence=VSP_029198;
CC Name=5; Synonyms=IL-17RE6;
CC IsoId=Q8BH06-5; Sequence=VSP_029197;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in mucosal tissues,
CC including trachea, lung, kidney and stomach. Highly expressed in colon
CC epithelial cells. Also expressed in testis. Low expression, if any, in
CC heart, liver, spleen, or brain. Among CD4 T-helper cells, expressed at
CC high levels in Th17 cells. {ECO:0000269|PubMed:16310341,
CC ECO:0000269|PubMed:21982598, ECO:0000269|PubMed:21993848,
CC ECO:0000269|PubMed:21993849}.
CC -!- DEVELOPMENTAL STAGE: Expression starts at 10.5 dpc and reaches a
CC plateau of expression at 12.5 dpc. {ECO:0000269|PubMed:16310341}.
CC -!- INDUCTION: Up-regulated by its own ligand IL17C. Also up-regulated by
CC IL6 and TNF acting synergically. This induction can be further
CC increased by IL23. {ECO:0000269|PubMed:21982598}.
CC -!- DISRUPTION PHENOTYPE: Mutant animals are born normally at the expected
CC Mendelian frequency. They exhibit much lower expression of genes
CC encoding antibacterial molecules, much greater bacterial burdens and
CC total mortality after infection with Citrobacter rodentium.
CC {ECO:0000269|PubMed:21993849}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC37436.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; DQ092339; AAZ85958.1; -; mRNA.
DR EMBL; DQ092340; AAZ85959.1; -; mRNA.
DR EMBL; DQ092341; AAZ85960.1; -; mRNA.
DR EMBL; AF458068; AAM77572.1; -; mRNA.
DR EMBL; AK046302; BAC32678.1; -; mRNA.
DR EMBL; AK046713; BAC32842.1; -; mRNA.
DR EMBL; AK078876; BAC37436.1; ALT_FRAME; mRNA.
DR EMBL; AK169498; BAE41201.1; -; mRNA.
DR EMBL; BC026737; AAH26737.1; -; mRNA.
DR EMBL; BC069861; AAH69861.1; -; mRNA.
DR CCDS; CCDS20420.1; -. [Q8BH06-1]
DR CCDS; CCDS20421.1; -. [Q8BH06-4]
DR CCDS; CCDS90101.1; -. [Q8BH06-2]
DR CCDS; CCDS90102.1; -. [Q8BH06-3]
DR RefSeq; NP_001029201.1; NM_001034029.1. [Q8BH06-4]
DR RefSeq; NP_001029203.1; NM_001034031.1. [Q8BH06-4]
DR RefSeq; NP_665825.2; NM_145826.5. [Q8BH06-1]
DR AlphaFoldDB; Q8BH06; -.
DR SMR; Q8BH06; -.
DR IntAct; Q8BH06; 2.
DR STRING; 10090.ENSMUSP00000062103; -.
DR GlyGen; Q8BH06; 2 sites.
DR PhosphoSitePlus; Q8BH06; -.
DR MaxQB; Q8BH06; -.
DR PaxDb; Q8BH06; -.
DR PRIDE; Q8BH06; -.
DR ProteomicsDB; 273077; -. [Q8BH06-1]
DR ProteomicsDB; 273078; -. [Q8BH06-2]
DR ProteomicsDB; 273079; -. [Q8BH06-3]
DR Antibodypedia; 2563; 324 antibodies from 31 providers.
DR DNASU; 57890; -.
DR Ensembl; ENSMUST00000053569; ENSMUSP00000054378; ENSMUSG00000043088. [Q8BH06-4]
DR Ensembl; ENSMUST00000058548; ENSMUSP00000062103; ENSMUSG00000043088. [Q8BH06-1]
DR Ensembl; ENSMUST00000101065; ENSMUSP00000098626; ENSMUSG00000043088. [Q8BH06-4]
DR Ensembl; ENSMUST00000203661; ENSMUSP00000145345; ENSMUSG00000043088. [Q8BH06-3]
DR Ensembl; ENSMUST00000204774; ENSMUSP00000145384; ENSMUSG00000043088. [Q8BH06-2]
DR GeneID; 57890; -.
DR KEGG; mmu:57890; -.
DR UCSC; uc009dgg.1; mouse. [Q8BH06-1]
DR UCSC; uc009dgj.1; mouse. [Q8BH06-5]
DR CTD; 132014; -.
DR MGI; MGI:1889371; Il17re.
DR VEuPathDB; HostDB:ENSMUSG00000043088; -.
DR eggNOG; ENOG502QU0I; Eukaryota.
DR GeneTree; ENSGT00940000161421; -.
DR HOGENOM; CLU_026094_0_0_1; -.
DR InParanoid; Q8BH06; -.
DR OMA; RIHATFS; -.
DR OrthoDB; 238258at2759; -.
DR PhylomeDB; Q8BH06; -.
DR TreeFam; TF335690; -.
DR BioGRID-ORCS; 57890; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Il17re; mouse.
DR PRO; PR:Q8BH06; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BH06; protein.
DR Bgee; ENSMUSG00000043088; Expressed in vestibular membrane of cochlear duct and 113 other tissues.
DR ExpressionAtlas; Q8BH06; baseline and differential.
DR Genevisible; Q8BH06; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030368; F:interleukin-17 receptor activity; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR InterPro; IPR039465; IL-17_rcpt-like.
DR InterPro; IPR027841; IL-17_rcpt_C/E_N.
DR InterPro; IPR013568; SEFIR_dom.
DR PANTHER; PTHR15583; PTHR15583; 2.
DR Pfam; PF15037; IL17_R_N; 2.
DR Pfam; PF08357; SEFIR; 1.
DR PROSITE; PS51534; SEFIR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Cytoplasm; Glycoprotein;
KW Inflammatory response; Membrane; Receptor; Reference proteome; Secreted;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..637
FT /note="Interleukin-17 receptor E"
FT /id="PRO_0000309468"
FT TOPO_DOM 24..414
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 436..637
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 447..583
FT /note="SEFIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00867"
FT REGION 87..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 278
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..326
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029197"
FT VAR_SEQ 1..201
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16310341"
FT /id="VSP_029198"
FT VAR_SEQ 410..455
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029199"
FT VAR_SEQ 410..442
FT /note="VSHRHLGLLILALLALTALVGVVLVLLGRRLLP -> DAPYPTQLLLRSL
FT (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_029200"
FT CONFLICT 377
FT /note="T -> M (in Ref. 4; AAH26737)"
FT /evidence="ECO:0000305"
FT CONFLICT 399
FT /note="H -> Q (in Ref. 4; AAH26737)"
FT /evidence="ECO:0000305"
FT CONFLICT 543
FT /note="A -> P (in Ref. 3; BAC37436)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 637 AA; 70833 MW; 5BFD2AB5128BB758 CRC64;
MGSPRLAALL LSLPLLLIGL AVSARVACPC LRSWTSHCLL AYRVDKRFAG LQWGWFPLLV
RKSKSPPKFE DYWRHRTPAS FQRKLLGSPS LSEESHRISI PSSAISHRGQ RTKRAQPSAA
EGREHLPEAG SQKCGGPEFS FDLLPEVQAV RVTIPAGPKA SVRLCYQWAL ECEDLSSPFD
TQKIVSGGHT VDLPYEFLLP CMCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWQSIRFTD
YSQHNQMVMA LTLRCPLKLE ASLCWRQDPL TPCETLPNAT AQESEGWYIL ENVDLHPQLC
FKFSFENSSH VECPHQSGSL PSWTVSMDTQ AQQLTLHFSS RTYATFSAAW SDPGLGPDTP
MPPVYSISQT QGSVPVTLDL IIPFLRQENC ILVWRSDVHF AWKHVLCPDV SHRHLGLLIL
ALLALTALVG VVLVLLGRRL LPGSGRTRPV LLLHAADSEA QRRLVGALAE LLRTALGGGR
DVIVDLWEGT HVARIGPLPW LWAARERVAR EQGTVLLLWN CAGPSTACSG DPQAASLRTL
LCAAPRPLLL AYFSRLCAKG DIPRPLRALP RYRLLRDLPR LLRALDAQPA TLASSWSHLG
AKRCLKNRLE QCHLLELEAA KDDYQGSTNS PCGFSCL
