ID   I17RE_RAT               Reviewed;         637 AA.
AC   Q6AZ51; Q6P7B8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Interleukin-17 receptor E;
DE            Short=IL-17 receptor E;
DE            Short=IL-17RE;
DE   Flags: Precursor;
GN   Name=Il17re;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung, and Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Specific functional receptor for IL17C, signaling through the
CC       NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling.
CC       Crucial regulator in innate immunity to bacterial pathogens (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms heterodimers with IL17RE; the heterodimer binds IL17C.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
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DR   EMBL; BC061739; AAH61739.1; -; mRNA.
DR   EMBL; BC078742; AAH78742.1; -; mRNA.
DR   RefSeq; NP_001004091.1; NM_001004091.1.
DR   RefSeq; XP_017448189.1; XM_017592700.1.
DR   AlphaFoldDB; Q6AZ51; -.
DR   SMR; Q6AZ51; -.
DR   STRING; 10116.ENSRNOP00000053347; -.
DR   GlyGen; Q6AZ51; 2 sites.
DR   PaxDb; Q6AZ51; -.
DR   PRIDE; Q6AZ51; -.
DR   Ensembl; ENSRNOT00000119312; ENSRNOP00000085698; ENSRNOG00000009204.
DR   GeneID; 362417; -.
DR   KEGG; rno:362417; -.
DR   UCSC; RGD:735148; rat.
DR   CTD; 132014; -.
DR   RGD; 735148; Il17re.
DR   eggNOG; ENOG502QU0I; Eukaryota.
DR   GeneTree; ENSGT00940000161421; -.
DR   HOGENOM; CLU_026094_0_0_1; -.
DR   InParanoid; Q6AZ51; -.
DR   OMA; RIHATFS; -.
DR   OrthoDB; 238258at2759; -.
DR   PhylomeDB; Q6AZ51; -.
DR   TreeFam; TF335690; -.
DR   PRO; PR:Q6AZ51; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000009204; Expressed in stomach and 16 other tissues.
DR   Genevisible; Q6AZ51; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030368; F:interleukin-17 receptor activity; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   InterPro; IPR039465; IL-17_rcpt-like.
DR   InterPro; IPR027841; IL-17_rcpt_C/E_N.
DR   InterPro; IPR013568; SEFIR_dom.
DR   PANTHER; PTHR15583; PTHR15583; 2.
DR   Pfam; PF15037; IL17_R_N; 1.
DR   Pfam; PF08357; SEFIR; 1.
DR   PROSITE; PS51534; SEFIR; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Inflammatory response; Membrane; Receptor;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..637
FT                   /note="Interleukin-17 receptor E"
FT                   /id="PRO_0000309469"
FT   TOPO_DOM        25..415
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        437..637
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          447..583
FT                   /note="SEFIR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00867"
FT   CARBOHYD        278
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        307
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   637 AA;  70852 MW;  BB6C71838AB1C9D5 CRC64;
     MGSPRLAALL LSQPLLFICL AVSAQVACPC LPRWTSHCLL AFRVDKHFAG LQCGWFPLLV
     RKSKSSHEFE VCWRHWTPSP FQRKLLGSPS LSQESHRIST HFLAISHRGL RTKRTQPSAA
     EGIEHLPGAG SQKHGGPEFS FDLLPEVQAI RVTIPPGPEA NVRLCYQWAL ECEDMSSPFD
     TQKIVSGGHT VDLPYEFLLP CMCIEASYLQ EDTVRHKKCP FRSWPEAYGS DFWKSIRFTD
     YSQHSQMVMA LTLRCPLKLE ASLCWRQDPV TPCKILPNAT AKESEGWYIL ENVDLHPQLC
     FKFSFENSSH VECPHQSGSL PSWTVSMDTQ AQQLILHFST RTYATFSAAW SNPGLGLDSS
     MTPVYSISQT QGSVPVTLNL IIPFLRQGSC ILVWRSDVQF AWKHLLCPDV SHRHLGLLIL
     ALLGLTTLLG VVLVLFCRRL LPGPGRTRPV LLLHAADSEA QRRLVGALAE LLRTALGGGR
     DVIVDLWEGT HVARIGPLPW LWAARERVAR EQGTVLLLWS CAGPSTACSG DPQTASLRTL
     SCAAPRQLLL AYFSRLCAKG DIPGPLRALP RYRLLRDLPR LLRALDARPA TLATSWSHLG
     AKECLKSRLE LCHLLELEAA KDDYHGSTNS PCGFSCL