ID   I1B1_CONCL              Reviewed;          78 AA.
AC   D6C4H9;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Conotoxin Cl11.1;
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA   Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA   Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA   Olivera B.M.;
RT   "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT   1844.";
RL   Mol. Phylogenet. Evol. 56:1-12(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FJ959121; ADB93091.1; -; Genomic_DNA.
DR   AlphaFoldDB; D6C4H9; -.
DR   SMR; D6C4H9; -.
DR   ConoServer; 4007; Cal11.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..33
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000415006"
FT   PEPTIDE         36..78
FT                   /note="Conotoxin Cl11.1"
FT                   /id="PRO_0000415007"
FT   DISULFID        47..61
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        54..66
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        60..70
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        65..77
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   78 AA;  8797 MW;  FB0664B3D52F8E38 CRC64;
     MKLALTFLLI LMILPLTTGG KKSDNQALKR LGARKFNENL SELNSACDDA WETCAWSRTC
     CSRNCCRGIC VSRYYECP