I1B1_CONEP
ID I1B1_CONEP Reviewed; 72 AA.
AC P0C253; D6C4G7;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Conotoxin Ep11.1;
DE Flags: Precursor;
OS Conus episcopatus (Bishop's cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Darioconus.
OX NCBI_TaxID=88764;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=16098199; DOI=10.1111/j.1742-4658.2005.04830.x;
RA Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RT "Characterization of D-amino-acid-containing excitatory conotoxins and
RT redefinition of the I-conotoxin superfamily.";
RL FEBS J. 272:4178-4188(2005).
RN [2]
RP ERRATUM OF PUBMED:16098199.
RA Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RL FEBS J. 272:4839-4839(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA Olivera B.M.;
RT "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT 1844.";
RL Mol. Phylogenet. Evol. 56:1-12(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
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DR EMBL; FJ959109; ADB93079.1; -; Genomic_DNA.
DR AlphaFoldDB; P0C253; -.
DR SMR; P0C253; -.
DR ConoServer; 1453; Ep11.1 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR013141; Conotoxin-I_CS.
DR PROSITE; PS60019; I_CONOTOXIN; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..32
FT /evidence="ECO:0000255"
FT /id="PRO_0000262677"
FT CHAIN 34..72
FT /note="Conotoxin Ep11.1"
FT /id="PRO_0000262678"
FT DISULFID 39..53
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 46..58
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 52..63
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 57..70
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ SEQUENCE 72 AA; 7431 MW; 891842A2474F92BB CRC64;
MKLCVTFLLI LVILPSVTGE KSSKRTLSGA ALRGDWGMCS GIGQGCGQDS NCCGDMCCYG
QICAMTFAAC GP