I1B1_CONMA
ID I1B1_CONMA Reviewed; 46 AA.
AC P0C257;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Iota-conotoxin-like M11.1;
DE Flags: Precursor; Fragment;
OS Conus magus (Magical cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX NCBI_TaxID=6492;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=16098199; DOI=10.1111/j.1742-4658.2005.04830.x;
RA Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RT "Characterization of D-amino-acid-containing excitatory conotoxins and
RT redefinition of the I-conotoxin superfamily.";
RL FEBS J. 272:4178-4188(2005).
RN [2]
RP ERRATUM OF PUBMED:16098199.
RA Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RL FEBS J. 272:4839-4839(2005).
CC -!- FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav)
CC and act as agonists by shifting the voltage-dependence of activation to
CC more hyperpolarized levels. Produces general excitatory symptoms (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C257; -.
DR ConoServer; 1420; M11.1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR013141; Conotoxin-I_CS.
DR InterPro; IPR012624; Toxin_19.
DR Pfam; PF08088; Toxin_19; 1.
DR PROSITE; PS60019; I_CONOTOXIN; 1.
PE 2: Evidence at transcript level;
KW D-amino acid; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT CHAIN <1..45
FT /note="Iota-conotoxin-like M11.1"
FT /id="PRO_0000262685"
FT PROPEP 46
FT /note="Removed by a carboxypeptidase"
FT /evidence="ECO:0000250"
FT /id="PRO_0000262686"
FT MOD_RES 44
FT /note="D-methionine"
FT /evidence="ECO:0000250"
FT DISULFID 5..19
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 12..22
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 18..27
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 21..38
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT NON_TER 1
SQ SEQUENCE 46 AA; 4832 MW; 3ECFBC8E501E11F5 CRC64;
GAVPCGKDGR QCRNHADCCN CCPIGTCAPS TNWILPGCST GQFMTR