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I1B1_CONMA
ID   I1B1_CONMA              Reviewed;          46 AA.
AC   P0C257;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Iota-conotoxin-like M11.1;
DE   Flags: Precursor; Fragment;
OS   Conus magus (Magical cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=6492;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16098199; DOI=10.1111/j.1742-4658.2005.04830.x;
RA   Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RT   "Characterization of D-amino-acid-containing excitatory conotoxins and
RT   redefinition of the I-conotoxin superfamily.";
RL   FEBS J. 272:4178-4188(2005).
RN   [2]
RP   ERRATUM OF PUBMED:16098199.
RA   Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RL   FEBS J. 272:4839-4839(2005).
CC   -!- FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav)
CC       and act as agonists by shifting the voltage-dependence of activation to
CC       more hyperpolarized levels. Produces general excitatory symptoms (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C257; -.
DR   ConoServer; 1420; M11.1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR012624; Toxin_19.
DR   Pfam; PF08088; Toxin_19; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   D-amino acid; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           <1..45
FT                   /note="Iota-conotoxin-like M11.1"
FT                   /id="PRO_0000262685"
FT   PROPEP          46
FT                   /note="Removed by a carboxypeptidase"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000262686"
FT   MOD_RES         44
FT                   /note="D-methionine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        5..19
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        12..22
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        18..27
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        21..38
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   NON_TER         1
SQ   SEQUENCE   46 AA;  4832 MW;  3ECFBC8E501E11F5 CRC64;
     GAVPCGKDGR QCRNHADCCN CCPIGTCAPS TNWILPGCST GQFMTR
 
 
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