ID   I1B1_CONXI              Reviewed;          76 AA.
AC   P0DW72;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Conopeptide X11.1 {ECO:0000305};
DE   AltName: Full=I1_xm11a {ECO:0000303|PubMed:29360782};
DE   Flags: Precursor;
OS   Conasprella ximenes (Interrupted cone) (Conus ximenes).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conasprella;
OC   Ximeniconus.
OX   NCBI_TaxID=257349;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 40-76, FUNCTION,
RP   SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=29360782; DOI=10.3390/toxins10020051;
RA   Figueroa-Montiel A., Bernaldez J., Jimenez S., Ueberhide B., Gonzalez L.J.,
RA   Licea-Navarro A.;
RT   "Antimycobacterial activity: a new pharmacological target for conotoxins
RT   found in the first reported conotoxin from Conasprella ximenes.";
RL   Toxins 10:0-0(2018).
CC   -!- FUNCTION: Antimicrobial peptide that potently inhibits growth of
CC       Mycobacterium tuberculosis (H37Rv strain) (MIC=3 uM).
CC       {ECO:0000269|PubMed:29360782}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29360782}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:29360782}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=4109.69; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:29360782};
CC   -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
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DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..39
FT                   /evidence="ECO:0000305|PubMed:29360782"
FT                   /id="PRO_0000456320"
FT   CHAIN           40..76
FT                   /note="Conopeptide X11.1"
FT                   /evidence="ECO:0000269|PubMed:29360782"
FT                   /id="PRO_0000456321"
FT   DISULFID        42..56
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        49..61
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        55..66
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        60..73
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   76 AA;  8371 MW;  3239A856048E8E50 CRC64;
     MMKLSVSFLL LLMLLPFITG EENSDSDVLK SGAAVRQGRG RCRGFREDCS QHRDCCGDLC
     CNGNTCVITV IACPKW