I1B2_CONCL
ID I1B2_CONCL Reviewed; 80 AA.
AC D6C4I0;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 1.
DT 25-MAY-2022, entry version 22.
DE RecName: Full=Conotoxin Cl11.2;
DE Flags: Precursor;
OS Californiconus californicus (California cone) (Conus californicus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX NCBI_TaxID=1736779;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA Olivera B.M.;
RT "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT 1844.";
RL Mol. Phylogenet. Evol. 56:1-12(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
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DR EMBL; FJ959122; ADB93092.1; -; Genomic_DNA.
DR AlphaFoldDB; D6C4I0; -.
DR SMR; D6C4I0; -.
DR ConoServer; 4008; Cal11.2 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR013141; Conotoxin-I_CS.
DR PROSITE; PS60019; I_CONOTOXIN; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Disulfide bond; Neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..41
FT /evidence="ECO:0000250"
FT /id="PRO_0000415008"
FT PEPTIDE 44..79
FT /note="Conotoxin Cl11.2"
FT /id="PRO_0000415009"
FT DISULFID 45..59
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 52..63
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 58..68
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 62..74
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ SEQUENCE 80 AA; 9189 MW; B18AD29812FEF8AE CRC64;
MKMSVTFLLI LMILPLFTGE WQSGSRLSAL KKRLLEKRLL QKRFCTEIGK DCGTSWECCE
DCCIHGTCSH ESNCANFKLR