ID   I1B3_CONRA              Reviewed;          75 AA.
AC   Q7Z090; D6C4H1;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Iota-conotoxin-like R11.3;
DE   Flags: Precursor;
OS   Conus radiatus (Rayed cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX   NCBI_TaxID=61198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16098199; DOI=10.1111/j.1742-4658.2005.04830.x;
RA   Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RT   "Characterization of D-amino-acid-containing excitatory conotoxins and
RT   redefinition of the I-conotoxin superfamily.";
RL   FEBS J. 272:4178-4188(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA   Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA   Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA   Olivera B.M.;
RT   "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT   1844.";
RL   Mol. Phylogenet. Evol. 56:1-12(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 36-75.
RC   TISSUE=Venom duct;
RX   PubMed=12694387; DOI=10.1046/j.1471-4159.2003.01685.x;
RA   Jimenez E.C., Shetty R.P., Lirazan M., Rivier J., Walker C., Abogadie F.C.,
RA   Yoshikami D., Cruz L.J., Olivera B.M.;
RT   "Novel excitatory Conus peptides define a new conotoxin superfamily.";
RL   J. Neurochem. 85:610-621(2003).
RN   [4]
RP   ERRATUM OF PUBMED:12694387.
RA   Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RL   FEBS J. 272:4839-4839(2005).
CC   -!- FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav)
CC       and act as agonists by shifting the voltage-dependence of activation to
CC       more hyperpolarized levels. Produces general excitatory symptoms (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
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DR   EMBL; AY208963; AAP41545.1; -; mRNA.
DR   EMBL; FJ959113; ADB93083.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7Z090; -.
DR   ConoServer; 1410; R11.3 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR012624; Toxin_19.
DR   Pfam; PF08088; Toxin_19; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..34
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000262447"
FT   CHAIN           36..75
FT                   /note="Iota-conotoxin-like R11.3"
FT                   /id="PRO_0000044882"
FT   DISULFID        39..53
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        46..58
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        52..63
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        57..70
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   75 AA;  8476 MW;  B871FC236DAA2D6D CRC64;
     MKLCLTFLLV LMILASVTGE KLSEQTLRRA ARKNKGPRCW VGRVHCTYHK DCCPSVCCFK
     GRCKPQSWGC WSGPT