ID   I1B3_CONTE              Reviewed;          71 AA.
AC   S4UKA9;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Conotoxin Tx11.3 {ECO:0000312|EMBL:AGK23268.1};
DE   Flags: Precursor;
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=24349297; DOI=10.1371/journal.pone.0082495;
RA   Wu Y., Wang L., Zhou M., You Y., Zhu X., Qiang Y., Qin M., Luo S., Ren Z.,
RA   Xu A.;
RT   "Molecular evolution and diversity of conus peptide toxins, as revealed by
RT   gene structure and intron sequence analyses.";
RL   PLoS ONE 8:E82495-E82495(2013).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=22709442; DOI=10.1021/pr300312h;
RA   Bhatia S., Kil Y.J., Ueberheide B., Chait B.T., Tayo L., Cruz L., Lu B.,
RA   Yates J.R. III, Bern M.;
RT   "Constrained de novo sequencing of conotoxins.";
RL   J. Proteome Res. 11:4191-4200(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22709442}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:22709442}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the I1 superfamily. {ECO:0000305}.
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DR   EMBL; JX293452; AGK23192.1; -; mRNA.
DR   EMBL; JX293528; AGK23268.1; -; Genomic_DNA.
DR   AlphaFoldDB; S4UKA9; -.
DR   SMR; S4UKA9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..47
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000445064"
FT   PEPTIDE         48..71
FT                   /note="Conotoxin Tx11.3"
FT                   /evidence="ECO:0000269|PubMed:22709442"
FT                   /id="PRO_5007726930"
FT   DISULFID        39..53
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        46..58
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        52..63
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        57..70
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   71 AA;  7540 MW;  8E03D97FFDB979D2 CRC64;
     MKLCVTFLLV LVILPSVTGV KSSERTLSGA ALRGDRGTCS GRGQECKHDS DCCGHLCCAG
     ITCQFTYIPC K