ID   I1B8_CONIM              Reviewed;          76 AA.
AC   A0A125S9E0;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Conotoxin Im11.8 {ECO:0000305};
DE   AltName: Full=Conopeptide im006 {ECO:0000303|PubMed:30893765, ECO:0000312|EMBL:AME17664.1};
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30893765; DOI=10.3390/md17030177;
RA   Jin A.H., Dutertre S., Dutt M., Lavergne V., Jones A., Lewis R.J.,
RA   Alewood P.F.;
RT   "Transcriptomic-proteomic correlation in the predation-evoked venom of the
RT   cone snail, Conus imperialis.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30893765}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30893765}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
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DR   EMBL; KT377400; AME17664.1; -; mRNA.
DR   AlphaFoldDB; A0A125S9E0; -.
DR   SMR; A0A125S9E0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Disulfide bond; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..42
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000450997"
FT   CHAIN           43..76
FT                   /note="Conotoxin Im11.8"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5007179701"
FT   DISULFID        43..58
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        51..63
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        57..68
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        62..75
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   76 AA;  8346 MW;  767E0C333240FD67 CRC64;
     MKLALTFLLI LMILPLMTGE KTSDDLELRG VESLRAIFRD RRCSDNIGAT CSDRFDCCGS
     MCCIGGQCVV TFAECS