ID   I1BA_CONRE              Reviewed;          44 AA.
AC   P84197;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Conotoxin Rg11a;
OS   Conus regius (Crown cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=101314;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000269|PubMed:15581690};
RX   PubMed=15581690; DOI=10.1016/j.toxicon.2004.09.018;
RA   Vianna Braga M.C., Konno K., Portaro F.C.V., Carlos de Freitas J.,
RA   Yamane T., Olivera B.M., Pimenta D.C.;
RT   "Mass spectrometric and high performance liquid chromatography profiling of
RT   the venom of the Brazilian vermivorous mollusk Conus regius: feeding
RT   behavior and identification of one novel conotoxin.";
RL   Toxicon 45:113-122(2005).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RC   TISSUE=Venom;
RA   Pimenta D.C.;
RL   Submitted (SEP-2004) to UniProtKB.
CC   -!- FUNCTION: Neurotoxin. Elicits hypersensibility when injected
CC       intracranially in mice. May act via potassium channel currents.
CC       {ECO:0000269|PubMed:15581690, ECO:0000269|Ref.2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15581690}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:15581690}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- MASS SPECTROMETRY: Mass=4695.61; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15581690};
CC   -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P84197; -.
DR   ConoServer; 1508; RgXIA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   CHAIN           1..44
FT                   /note="Conotoxin Rg11a"
FT                   /id="PRO_0000086876"
FT   DISULFID        1..15
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        8..22
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        14..30
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        21..36
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   44 AA;  4703 MW;  3B2D0D25718D234B CRC64;
     CQAYGESCSA VVRCCDPNAV CCQYPEDAVC VTRGYCRPPA TVLT