ID   I1BE_CONRA              Reviewed;          37 AA.
AC   Q7M4K5;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Conotoxin r11e;
OS   Conus radiatus (Rayed cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX   NCBI_TaxID=61198;
RN   [1]
RP   PROTEIN SEQUENCE, GAMMA-CARBOXYGLUTAMATION AT GLU-13 AND GLU-14,
RP   BROMINATION AT TRP-34, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=12694387; DOI=10.1046/j.1471-4159.2003.01685.x;
RA   Jimenez E.C., Shetty R.P., Lirazan M., Rivier J., Walker C., Abogadie F.C.,
RA   Yoshikami D., Cruz L.J., Olivera B.M.;
RT   "Novel excitatory Conus peptides define a new conotoxin superfamily.";
RL   J. Neurochem. 85:610-621(2003).
CC   -!- FUNCTION: Causes hyperactivity, circular motion, convulsion, urination
CC       and death, when injected into 13- to 15-day-old mice. Causes gasping,
CC       backward swimming or swimming in a vertical direction and death, when
CC       intraperitoneally injected into goldfish.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- MASS SPECTROMETRY: Mass=4463.67; Method=Unknown;
CC       Evidence={ECO:0000269|PubMed:12694387};
CC   -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. {ECO:0000305}.
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DR   PIR; A59457; A59457.
DR   AlphaFoldDB; Q7M4K5; -.
DR   ConoServer; 1478; RXIE.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR012624; Toxin_19.
DR   Pfam; PF08088; Toxin_19; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Bromination; Direct protein sequencing; Disulfide bond;
KW   Gamma-carboxyglutamic acid; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin.
FT   CHAIN           1..37
FT                   /note="Conotoxin r11e"
FT                   /id="PRO_0000044883"
FT   MOD_RES         13
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000269|PubMed:12694387"
FT   MOD_RES         14
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000269|PubMed:12694387"
FT   MOD_RES         34
FT                   /note="6'-bromotryptophan"
FT                   /evidence="ECO:0000269|PubMed:12694387"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        9..21
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        15..26
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        20..33
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   37 AA;  4304 MW;  82A9AAF718D29F35 CRC64;
     ECKTNKMSCS LHEECCRFRC CFHGKCQTSV FGCWVDP