ID   I1_VACCA                Reviewed;         312 AA.
AC   O93117;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=Telomere-binding protein I1;
GN   OrderedLocusNames=MVA062L, ACAM3000_MVA_062; ORFNames=I1L;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Late DNA-binding protein which binds to the hairpin form of
CC       the viral telomeric sequence. Required for the production of mature
CC       virions (MV) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Present in the virus
CC       core. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- MISCELLANEOUS: Each virion contains approximately 670 molecules of I1.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I1 family. {ECO:0000305}.
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DR   EMBL; U94848; AAB96433.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10460.1; -; Genomic_DNA.
DR   PIR; T37338; T37338.
DR   SMR; O93117; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004969; Poxvirus_I1.
DR   Pfam; PF03289; Pox_I1; 1.
DR   PIRSF; PIRSF015625; VAC_I1L; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Late protein; Virion.
FT   CHAIN           1..312
FT                   /note="Telomere-binding protein I1"
FT                   /id="PRO_0000099557"
SQ   SEQUENCE   312 AA;  35883 MW;  F9DD56C3F4634B8E CRC64;
     MAEFEDQLVF NSISARALKA YFTAKINEMV DELVTRKCPQ KKKSQAKKPE LRIPVDLVKS
     SFVKKFGLCN YGGILISLIN SLVENNFFTK DGKLDDTGKK ELVLTDVEKR ILNTIDKSSP
     LYIDISDVKV LAARLKRSAT QFNFNGHTYH LENDKIEDLI NQLVKDESIQ LDEKSSIKDS
     MYVIPDELID VLKTRLFRSP QVKDNIISRT RLYDYFTRVT KRDESSIYVI LKDPRIASIL
     SLETVKMGAF MYTKHSMLTN AISSRVDRYS KKFQESFYED IVEFVKENER VNVSRVVECL
     TVPNITISSN AE