ID   I1_VACCW                Reviewed;         312 AA.
AC   P16714; Q76ZV2; Q85324;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   23-FEB-2022, entry version 65.
DE   RecName: Full=Telomere-binding protein I1;
GN   OrderedLocusNames=VACWR070; ORFNames=I1L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
RX   PubMed=2835495; DOI=10.1128/jvi.62.6.1889-1897.1988;
RA   Schmitt J.F.C., Stunnenberg H.G.;
RT   "Sequence and transcriptional analysis of the vaccinia virus HindIII I
RT   fragment.";
RL   J. Virol. 62:1889-1897(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-312.
RX   PubMed=1496000; DOI=10.1073/pnas.89.15.7060;
RA   Ahn B.-Y., Moss B.;
RT   "Glutaredoxin homolog encoded by vaccinia virus is a virion-associated
RT   enzyme with thioltransferase and dehydroascorbate reductase activities.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:7060-7064(1992).
RN   [4]
RP   PROTEIN SEQUENCE OF 3-11, IDENTIFICATION, INDUCTION, DNA-BINDING, AND
RP   FUNCTION.
RX   PubMed=9371587; DOI=10.1128/jvi.71.12.9285-9294.1997;
RA   Klemperer N., Ward J., Evans E., Traktman P.;
RT   "The vaccinia virus I1 protein is essential for the assembly of mature
RT   virions.";
RL   J. Virol. 71:9285-9294(1997).
RN   [5]
RP   PROTEIN SEQUENCE OF 2-16 AND 236-246, AND FUNCTION.
RX   PubMed=11581377; DOI=10.1128/jvi.75.21.10090-10105.2001;
RA   DeMasi J., Du S., Lennon D., Traktman P.;
RT   "Vaccinia virus telomeres: interaction with the viral I1, I6, and K4
RT   proteins.";
RL   J. Virol. 75:10090-10105(2001).
CC   -!- FUNCTION: Late DNA-binding protein which binds to the hairpin form of
CC       the viral telomeric sequence. Required for the production of mature
CC       virions (MV). {ECO:0000269|PubMed:11581377,
CC       ECO:0000269|PubMed:9371587}.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Present in the virus core.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:9371587}.
CC   -!- MISCELLANEOUS: Each virion contains approximately 670 molecules of I1.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I1 family. {ECO:0000305}.
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DR   EMBL; AY243312; AAO89349.1; -; Genomic_DNA.
DR   EMBL; J03399; AAB59803.1; -; Genomic_DNA.
DR   EMBL; M76472; AAA48250.1; -; Genomic_DNA.
DR   RefSeq; YP_232952.1; NC_006998.1.
DR   SMR; P16714; -.
DR   IntAct; P16714; 1.
DR   MINT; P16714; -.
DR   DNASU; 3707603; -.
DR   GeneID; 3707603; -.
DR   KEGG; vg:3707603; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004969; Poxvirus_I1.
DR   Pfam; PF03289; Pox_I1; 1.
DR   PIRSF; PIRSF015625; VAC_I1L; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; DNA-binding; Late protein; Reference proteome;
KW   Virion.
FT   CHAIN           1..312
FT                   /note="Telomere-binding protein I1"
FT                   /id="PRO_0000099561"
FT   CONFLICT        103
FT                   /note="V -> A (in Ref. 3; AAA48250)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   312 AA;  35841 MW;  A7C17EA3F466679F CRC64;
     MAEFEDQLVF NSISARALKA YFTAKINEMV DELVTRKCPQ KKKSQAKKPE VRIPVDLVKS
     SFVKKFGLCN YGGILISLIN SLVENNFFTK DGKLDDTGKK ELVLTDVEKR ILNTIDKSSP
     LYIDISDVKV LAARLKRSAT QFNFNGHTYH LENDKIEDLI NQLVKDESIQ LDEKSSIKDS
     MYVIPDELID VLKTRLFRSP QVKDNIISRT RLYDYFTRVT KRDESSIYVI LKDPRIASIL
     SLETVKMGAF MYTKHSMLTN AISSRVDRYS KKFQESFYED IAEFVKENER VNVSRVVECL
     TVPNITISSN AE