ID   I1_VAR67                Reviewed;         312 AA.
AC   P32999;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Telomere-binding protein I1;
GN   ORFNames=I1L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383392; DOI=10.1016/0168-1702(93)90110-9;
RA   Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S.,
RA   Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V.,
RA   Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G.,
RA   Sandakhchiev L.S.;
RT   "Nucleotide sequence analysis of variola virus HindIII M, L, I genome
RT   fragments.";
RL   Virus Res. 27:25-35(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Late DNA-binding protein which binds to the hairpin form of
CC       the viral telomeric sequence. Required for the production of mature
CC       virions (MV) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Present in the virus
CC       core. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- MISCELLANEOUS: Each virion contains approximately 670 molecules of I1.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I1 family. {ECO:0000305}.
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DR   EMBL; X67119; CAA47555.1; -; Genomic_DNA.
DR   EMBL; X69198; CAA48996.1; -; Genomic_DNA.
DR   PIR; S33070; S33070.
DR   RefSeq; NP_042099.1; NC_001611.1.
DR   SMR; P32999; -.
DR   GeneID; 1486456; -.
DR   KEGG; vg:1486456; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004969; Poxvirus_I1.
DR   Pfam; PF03289; Pox_I1; 1.
DR   PIRSF; PIRSF015625; VAC_I1L; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Late protein; Reference proteome; Virion.
FT   CHAIN           1..312
FT                   /note="Telomere-binding protein I1"
FT                   /id="PRO_0000099562"
SQ   SEQUENCE   312 AA;  35736 MW;  A455F0E6790427C0 CRC64;
     MVEFEDQLVF NSISARALKA YFTAKINEMV DELVTRKCPQ KKKSQAKKPE VRIPVDLVKS
     SFVKKFGLCN YGGILISLIN SLVENNFFTK NGKLDDTGKK ELVLTDVEKR ILNTVDKSSP
     LYIDISDVKV LAARLKRSAT QFNFNGHTYH LENDKIEDLI NQLVKDESIQ LDEKSSIKDS
     MYVIPDELID VLKTRSFRSP QVKDNIISST RLYDYFTRVT KRDESSIYVI LKDPRIASIL
     SLETVEMGAF MYTKHSMLTN AISSEVDRYS EKFQESFYED IAEFVEENER VDVSRVVECL
     TVPNITISSN AE