I20L2_BOVIN
ID I20L2_BOVIN Reviewed; 349 AA.
AC Q2YDK1;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Interferon-stimulated 20 kDa exonuclease-like 2;
DE EC=3.1.-.-;
GN Name=ISG20L2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-> 5'-exoribonuclease involved in ribosome biogenesis in
CC the processing of the 12S pre-rRNA. Displays a strong specificity for a
CC 3'-end containing a free hydroxyl group. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC110186; AAI10187.1; -; mRNA.
DR RefSeq; NP_001039682.1; NM_001046217.2.
DR AlphaFoldDB; Q2YDK1; -.
DR SMR; Q2YDK1; -.
DR STRING; 9913.ENSBTAP00000001989; -.
DR PaxDb; Q2YDK1; -.
DR PRIDE; Q2YDK1; -.
DR Ensembl; ENSBTAT00000001989; ENSBTAP00000001989; ENSBTAG00000001518.
DR Ensembl; ENSBTAT00000078425; ENSBTAP00000058250; ENSBTAG00000001518.
DR GeneID; 515980; -.
DR KEGG; bta:515980; -.
DR CTD; 81875; -.
DR VEuPathDB; HostDB:ENSBTAG00000001518; -.
DR VGNC; VGNC:30295; ISG20L2.
DR eggNOG; KOG2249; Eukaryota.
DR GeneTree; ENSGT00940000159724; -.
DR HOGENOM; CLU_022453_0_0_1; -.
DR InParanoid; Q2YDK1; -.
DR OMA; PCPIVDY; -.
DR OrthoDB; 1562214at2759; -.
DR TreeFam; TF354340; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000001518; Expressed in rumen papilla and 102 other tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR CDD; cd06149; ISG20; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR037433; ISG20_DEDDh.
DR InterPro; IPR034933; ISG20L2.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR12801:SF78; PTHR12801:SF78; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 2: Evidence at transcript level;
KW Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW Ribosome biogenesis.
FT CHAIN 1..349
FT /note="Interferon-stimulated 20 kDa exonuclease-like 2"
FT /id="PRO_0000354703"
FT DOMAIN 175..331
FT /note="Exonuclease"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..39
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 349 AA; 38639 MW; 1A9F7CA7C25682FB CRC64;
MSTLLLNLDF GEPPPKKALE GNAKHRKFVK KRRLLERKGF LNKKKQPPSK VPKLHSEPSQ
KGETPRVDGT WKATPLPKKK TTAASSSGSE QSLDKKAAVP WLTPAPSQKA GSVVAKVDLL
GEFQSALPKI KSHPTRPQKK GSQKNPPPKN GPQNSTHTHS ENKYSGVSQK IPGKMVAIDC
EMVGTGPKGH VSSLARCSIV NYDGDVLYDE YILPPCHIVD YRTRWSGIRK QHMVNATPFK
IARNQILKIL AGKIVVGHAI HNDFKALQYI HPKSLTRDTS HIPLLNRKAD CPENATMSLK
SLTKKLLNRD IQAGKSGHSS VEDAQATMEL YKLVEVEWEQ HLAQNPPKD
