ID   I20L2_RAT               Reviewed;         369 AA.
AC   Q6AXU3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Interferon-stimulated 20 kDa exonuclease-like 2;
DE            EC=3.1.-.-;
GN   Name=Isg20l2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: 3'-> 5'-exoribonuclease involved in ribosome biogenesis in
CC       the processing of the 12S pre-rRNA. Displays a strong specificity for a
CC       3'-end containing a free hydroxyl group (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; BC079314; AAH79314.1; -; mRNA.
DR   RefSeq; NP_001007742.1; NM_001007741.1.
DR   AlphaFoldDB; Q6AXU3; -.
DR   SMR; Q6AXU3; -.
DR   STRING; 10116.ENSRNOP00000015471; -.
DR   PaxDb; Q6AXU3; -.
DR   Ensembl; ENSRNOT00000015471; ENSRNOP00000015471; ENSRNOG00000011402.
DR   GeneID; 361977; -.
DR   KEGG; rno:361977; -.
DR   UCSC; RGD:1359413; rat.
DR   CTD; 81875; -.
DR   RGD; 1359413; Isg20l2.
DR   eggNOG; KOG2249; Eukaryota.
DR   GeneTree; ENSGT00940000159724; -.
DR   HOGENOM; CLU_022453_0_0_1; -.
DR   InParanoid; Q6AXU3; -.
DR   OMA; PCPIVDY; -.
DR   OrthoDB; 1562214at2759; -.
DR   PhylomeDB; Q6AXU3; -.
DR   TreeFam; TF354340; -.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q6AXU3; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000011402; Expressed in testis and 19 other tissues.
DR   Genevisible; Q6AXU3; RN.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   CDD; cd06149; ISG20; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR037433; ISG20_DEDDh.
DR   InterPro; IPR034933; ISG20L2.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR12801:SF78; PTHR12801:SF78; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   2: Evidence at transcript level;
KW   Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..369
FT                   /note="Interferon-stimulated 20 kDa exonuclease-like 2"
FT                   /id="PRO_0000315281"
FT   DOMAIN          194..369
FT                   /note="Exonuclease"
FT   REGION          36..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..95
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  41311 MW;  02D2059586F5A85F CRC64;
     MSTILLNLDF GEPSKKAFGG NAKHQRFVKK RRFLEQKGFL SKKNQPPSKV SKLNSEPPKK
     GETSRVDSIS KILSCLKKKK EAAASKRDSE QSKDKKASLS WLTPAPSKKT DSVVAKIDLL
     GEFQSALPKP KRRTQKKGSK KPLKKKIATE NSTQTQSKDK GSNKKPLKKN AVQNSTQAQP
     EDKCPKVPQS LPRKMVAIDC EMVGTGPKGR VSSLARCSIV NYNGDVLYDE YIRPPCYIVD
     YRTRWSGIRK CHMVNATPFK TARSQILKIL SGKVVVGHAI HNDYKALQYF HPKSLTRDTS
     QIPLLNRKAD CPENVTLSLK HLTKKLLSRD IQTGLSGHSS VEDAQATLEL YKLVEVEWEQ
     HLAQNPPEN