I20RA_MOUSE
ID I20RA_MOUSE Reviewed; 546 AA.
AC Q6PHB0; Q8BW64;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Interleukin-20 receptor subunit alpha;
DE Short=IL-20 receptor subunit alpha;
DE Short=IL-20R-alpha;
DE Short=IL-20RA;
DE AltName: Full=IL-20R1;
DE Flags: Precursor;
GN Name=Il20ra;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Oviduct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and
CC IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with IL20RB and heterodimer with IL10RB.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC {ECO:0000305}.
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DR EMBL; AK054215; BAC35695.1; -; mRNA.
DR EMBL; BC056628; AAH56628.1; -; mRNA.
DR CCDS; CCDS23718.1; -.
DR RefSeq; NP_766374.1; NM_172786.2.
DR RefSeq; XP_006512789.1; XM_006512726.1.
DR AlphaFoldDB; Q6PHB0; -.
DR SMR; Q6PHB0; -.
DR STRING; 10090.ENSMUSP00000020185; -.
DR GlyGen; Q6PHB0; 5 sites.
DR PaxDb; Q6PHB0; -.
DR PRIDE; Q6PHB0; -.
DR Antibodypedia; 33022; 385 antibodies from 30 providers.
DR DNASU; 237313; -.
DR Ensembl; ENSMUST00000020185; ENSMUSP00000020185; ENSMUSG00000020007.
DR GeneID; 237313; -.
DR KEGG; mmu:237313; -.
DR UCSC; uc007eni.1; mouse.
DR CTD; 53832; -.
DR MGI; MGI:3605069; Il20ra.
DR VEuPathDB; HostDB:ENSMUSG00000020007; -.
DR eggNOG; ENOG502RPFC; Eukaryota.
DR GeneTree; ENSGT00940000157314; -.
DR HOGENOM; CLU_527430_0_0_1; -.
DR InParanoid; Q6PHB0; -.
DR OMA; MINFITL; -.
DR OrthoDB; 1078220at2759; -.
DR PhylomeDB; Q6PHB0; -.
DR TreeFam; TF334107; -.
DR Reactome; R-MMU-8854691; Interleukin-20 family signaling.
DR BioGRID-ORCS; 237313; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q6PHB0; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q6PHB0; protein.
DR Bgee; ENSMUSG00000020007; Expressed in skin of external ear and 24 other tissues.
DR ExpressionAtlas; Q6PHB0; baseline and differential.
DR Genevisible; Q6PHB0; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0042015; F:interleukin-20 binding; IPI:MGI.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IMP:MGI.
DR GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IGI:MGI.
DR GO; GO:0045124; P:regulation of bone resorption; IMP:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015713; IL-20_rcpt_alpha.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR PANTHER; PTHR20859:SF21; PTHR20859:SF21; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..546
FT /note="Interleukin-20 receptor subunit alpha"
FT /id="PRO_0000011037"
FT TOPO_DOM 33..253
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..546
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 42..138
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 139..245
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 90..98
FT /evidence="ECO:0000250"
FT DISULFID 218..239
FT /evidence="ECO:0000250"
FT CONFLICT 145
FT /note="V -> I (in Ref. 2; AAH56628)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 546 AA; 61978 MW; E7EC07DA2D49AF7F CRC64;
MHTPGTPAPG HPDPPPLLLL TLLLLLAASG RAVPCVFCGL PKPTNITFLS INMKNVLHWN
PPESLHGVEV TYTVQYFIYG QKKWLNASKC GSINRTYCDL SVETSDYEHQ FYAKVKAIWE
ARCSEWAETE RFYPFLETQV SPPEVALTTG EKSISIALTA PEKWKRNPQD HTVSMQQIYP
NLKYNVSVYN TKSRRTWSQC VTNSTLVLSW LEPNTLYCVH VESLVPGPPR LPMPSQKQCI
STLEVQTSAW KAKVIFWYVF LTSVIVFLFS AIGYLVYRYI HVGKEKHPAN LVLIYRNEIG
TRVFEPTETI TLNFITFSML DDTKISPKDM NLLDKSSDDI SVNDPEHNEA WEPHWEEVEG
QHLGCSSHLM DAVCGAEQRD GDTSLTQHGW LNSTIPTGET DTEPQYKVLS DFYGEGEIQL
SCEPEEAART EKISEPLVTS ANLDPQLEDL HHLGQEHTVS EDGPEEETSI TVVDWDPQTG
RLCIPSLPIF GRDPENYGHY ERDQLLEGGL LSRLYENQAP DKPEKENENC LTRFMEEWGL
HVQMES
