I20RB_HUMAN
ID I20RB_HUMAN Reviewed; 311 AA.
AC Q6UXL0; B4DL40; Q6P438; Q8IYY5; Q8TAJ7;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Interleukin-20 receptor subunit beta;
DE Short=IL-20 receptor subunit beta;
DE Short=IL-20R-beta;
DE Short=IL-20RB;
DE AltName: Full=Fibronectin type III domain containing 6;
DE Short=FNDC6;
DE AltName: Full=IL-20R2;
DE Flags: Precursor;
GN Name=IL20RB; Synonyms=DIRS1; ORFNames=UNQ557/PRO1114;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Thalamus, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 30-44.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [7]
RP SUBUNIT, LIGAND-BINDING, AND TISSUE SPECIFICITY.
RX PubMed=11163236; DOI=10.1016/s0092-8674(01)00187-8;
RA Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S.,
RA Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L.,
RA Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J., Prunkard D.,
RA Sexson S., Sprecher C., Waggie K., West J., Whitmore T.E., Yao L.,
RA Kuechle M.K., Dale B.A., Chandrasekher Y.A.;
RT "Interleukin 20: discovery, receptor identification, and role in epidermal
RT function.";
RL Cell 104:9-19(2001).
RN [8]
RP SUBUNIT, AND LIGAND-BINDING.
RX PubMed=11564763; DOI=10.4049/jimmunol.167.7.3545;
RA Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.;
RT "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes
RT of two types.";
RL J. Immunol. 167:3545-3549(2001).
RN [9]
RP SUBUNIT, AND LIGAND-BINDING.
RX PubMed=12351624; DOI=10.1074/jbc.m205114200;
RA Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C.,
RA Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S.,
RA Chandrasekher Y.A.;
RT "Interleukins 19, 20, and 24 signal through two distinct receptor
RT complexes. Differences in receptor-ligand interactions mediate unique
RT biological functions.";
RL J. Biol. Chem. 277:47517-47523(2002).
RN [10]
RP SUBUNIT, AND LIGAND-BINDING.
RX PubMed=14580208; DOI=10.1021/bi0354583;
RA Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A.,
RA Zdanov A.;
RT "Characterization of the recombinant extracellular domains of human
RT interleukin-20 receptors and their complexes with interleukin-19 and
RT interleukin-20.";
RL Biochemistry 42:12617-12624(2003).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-231 IN COMPLEX WITH IL20RA AND
RP IL20, SUBUNIT, AND DISULFIDE BONDS.
RX PubMed=22802649; DOI=10.1073/pnas.1117551109;
RA Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.;
RT "Structural basis for receptor sharing and activation by interleukin-20
RT receptor-2 (IL-20R2) binding cytokines.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012).
CC -!- FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and
CC IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.
CC -!- SUBUNIT: Heterodimer with IL20RA and heterodimer with IL22RA1.
CC {ECO:0000269|PubMed:11163236, ECO:0000269|PubMed:11564763,
CC ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:14580208,
CC ECO:0000269|PubMed:22802649}.
CC -!- INTERACTION:
CC Q6UXL0; PRO_0000015379 [Q9UHD0]: IL19; NbExp=4; IntAct=EBI-14022792, EBI-14023330;
CC Q6UXL0; PRO_0000015381 [Q9NYY1]: IL20; NbExp=5; IntAct=EBI-14022792, EBI-14022785;
CC Q6UXL0; P21145: MAL; NbExp=3; IntAct=EBI-14022792, EBI-3932027;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UXL0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UXL0-3; Sequence=VSP_054905, VSP_054906, VSP_054907;
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in skin and
CC testis. Highly expressed in psoriatic skin.
CC {ECO:0000269|PubMed:11163236}.
CC -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC {ECO:0000305}.
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DR EMBL; AY358305; AAQ88672.1; -; mRNA.
DR EMBL; AK296832; BAG59402.1; -; mRNA.
DR EMBL; AK316084; BAH14455.1; -; mRNA.
DR EMBL; AC011597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79101.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79104.1; -; Genomic_DNA.
DR EMBL; BC033292; AAH33292.1; -; mRNA.
DR EMBL; BC063696; AAH63696.2; -; mRNA.
DR CCDS; CCDS3093.1; -. [Q6UXL0-1]
DR RefSeq; NP_653318.2; NM_144717.3. [Q6UXL0-1]
DR PDB; 4DOH; X-ray; 2.80 A; B/D=30-231.
DR PDB; 6DF3; X-ray; 2.15 A; H=35-224.
DR PDBsum; 4DOH; -.
DR PDBsum; 6DF3; -.
DR AlphaFoldDB; Q6UXL0; -.
DR SMR; Q6UXL0; -.
DR BioGRID; 119805; 37.
DR IntAct; Q6UXL0; 14.
DR STRING; 9606.ENSP00000328133; -.
DR GlyGen; Q6UXL0; 2 sites.
DR iPTMnet; Q6UXL0; -.
DR PhosphoSitePlus; Q6UXL0; -.
DR BioMuta; IL20RB; -.
DR DMDM; 51701521; -.
DR EPD; Q6UXL0; -.
DR MassIVE; Q6UXL0; -.
DR PaxDb; Q6UXL0; -.
DR PeptideAtlas; Q6UXL0; -.
DR PRIDE; Q6UXL0; -.
DR Antibodypedia; 17858; 276 antibodies from 28 providers.
DR DNASU; 53833; -.
DR Ensembl; ENST00000329582.9; ENSP00000328133.4; ENSG00000174564.13. [Q6UXL0-1]
DR GeneID; 53833; -.
DR KEGG; hsa:53833; -.
DR MANE-Select; ENST00000329582.9; ENSP00000328133.4; NM_144717.4; NP_653318.2.
DR UCSC; uc003eri.3; human. [Q6UXL0-1]
DR CTD; 53833; -.
DR DisGeNET; 53833; -.
DR GeneCards; IL20RB; -.
DR HGNC; HGNC:6004; IL20RB.
DR HPA; ENSG00000174564; Group enriched (esophagus, skin, vagina).
DR MIM; 605621; gene.
DR neXtProt; NX_Q6UXL0; -.
DR OpenTargets; ENSG00000174564; -.
DR PharmGKB; PA29819; -.
DR VEuPathDB; HostDB:ENSG00000174564; -.
DR eggNOG; ENOG502S2V6; Eukaryota.
DR GeneTree; ENSGT00510000048354; -.
DR HOGENOM; CLU_074126_1_0_1; -.
DR InParanoid; Q6UXL0; -.
DR OMA; EFLVVYW; -.
DR OrthoDB; 915838at2759; -.
DR PhylomeDB; Q6UXL0; -.
DR TreeFam; TF332537; -.
DR PathwayCommons; Q6UXL0; -.
DR Reactome; R-HSA-8854691; Interleukin-20 family signaling.
DR SignaLink; Q6UXL0; -.
DR SIGNOR; Q6UXL0; -.
DR BioGRID-ORCS; 53833; 7 hits in 1079 CRISPR screens.
DR GeneWiki; Interleukin_20_receptor,_beta_subunit; -.
DR GenomeRNAi; 53833; -.
DR Pharos; Q6UXL0; Tbio.
DR PRO; PR:Q6UXL0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6UXL0; protein.
DR Bgee; ENSG00000174564; Expressed in upper arm skin and 110 other tissues.
DR ExpressionAtlas; Q6UXL0; baseline and differential.
DR Genevisible; Q6UXL0; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0042015; F:interleukin-20 binding; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR GO; GO:0002765; P:immune response-inhibiting signal transduction; IEA:Ensembl.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0001808; P:negative regulation of type IV hypersensitivity; IEA:Ensembl.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
DR GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Direct protein sequencing;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 30..311
FT /note="Interleukin-20 receptor subunit beta"
FT /id="PRO_0000011038"
FT TOPO_DOM 30..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 37..136
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 144..228
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 89..97
FT /evidence="ECO:0000269|PubMed:22802649"
FT DISULFID 202..223
FT /evidence="ECO:0000269|PubMed:22802649"
FT VAR_SEQ 1..47
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054905"
FT VAR_SEQ 179..194
FT /note="HVKMVRSGGIPVHLET -> RPFPWYWPCLPLLASC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054906"
FT VAR_SEQ 195..311
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054907"
FT STRAND 42..46
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 49..53
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 60..62
FT /evidence="ECO:0007829|PDB:4DOH"
FT STRAND 65..71
FT /evidence="ECO:0007829|PDB:6DF3"
FT HELIX 73..78
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 90..92
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 94..98
FT /evidence="ECO:0007829|PDB:6DF3"
FT HELIX 100..102
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 105..117
FT /evidence="ECO:0007829|PDB:6DF3"
FT HELIX 133..135
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 143..148
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 151..156
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 164..175
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 179..183
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 190..194
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 197..199
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 201..208
FT /evidence="ECO:0007829|PDB:6DF3"
FT TURN 210..212
FT /evidence="ECO:0007829|PDB:6DF3"
FT STRAND 222..224
FT /evidence="ECO:0007829|PDB:4DOH"
SQ SEQUENCE 311 AA; 35076 MW; FF366D518116D9E3 CRC64;
MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH LLMWSPVIAP
GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT DDITATVPYN LRVRATLGSQ
TSAWSILKHP FNRNSTILTR PGMEITKDGF HLVIELEDLG PQFEFLVAYW RREPGAEEHV
KMVRSGGIPV HLETMEPGAA YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF
VGFMLILVVV PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM
SPEELLRAWI S
