I22R1_MOUSE
ID I22R1_MOUSE Reviewed; 581 AA.
AC Q80XZ4; B2RU51; Q3URP9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Interleukin-22 receptor subunit alpha-1;
DE Short=IL-22 receptor subunit alpha-1;
DE Short=IL-22R-alpha-1;
DE Short=IL-22RA1;
DE Flags: Precursor;
GN Name=Il22ra1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=12618864; DOI=10.1038/sj.gene.6363934;
RA Tachiiri A., Imamura R., Wang Y., Fukui M., Umemura M., Suda T.;
RT "Genomic structure and inducible expression of the IL-22 receptor alpha
RT chain in mice.";
RL Genes Immun. 4:153-159(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the receptor for IL20, IL22 and IL24. Component
CC of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling
CC via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and
CC Akt kinases pathways. Component of one of the receptor for IL20 and
CC IL24 formed by IL22RA1 and IL20RB also signaling through STATs
CC activation. Mediates IL24 antiangiogenic activity as well as IL24
CC inhibitory effect on endothelial cell tube formation and
CC differentiation. {ECO:0000269|PubMed:12618864}.
CC -!- SUBUNIT: Heterodimer with IL10RB and with IL20RB. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in kidney, liver and lung.
CC {ECO:0000269|PubMed:12618864}.
CC -!- INDUCTION: By LPS stimulation in the liver.
CC {ECO:0000269|PubMed:12618864}.
CC -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC {ECO:0000305}.
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DR EMBL; AY103454; AAM52222.1; -; mRNA.
DR EMBL; AK141289; BAE24639.1; -; mRNA.
DR EMBL; AL662911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140972; AAI40973.1; -; mRNA.
DR EMBL; BC140973; AAI40974.1; -; mRNA.
DR CCDS; CCDS18789.1; -.
DR RefSeq; NP_839988.1; NM_178257.2.
DR PDB; 6WEO; X-ray; 2.60 A; 1/4/7/A/B/F/I/M/P/S/V/Y=24-224.
DR PDBsum; 6WEO; -.
DR AlphaFoldDB; Q80XZ4; -.
DR SMR; Q80XZ4; -.
DR STRING; 10090.ENSMUSP00000099605; -.
DR GlyGen; Q80XZ4; 2 sites.
DR iPTMnet; Q80XZ4; -.
DR PhosphoSitePlus; Q80XZ4; -.
DR jPOST; Q80XZ4; -.
DR PaxDb; Q80XZ4; -.
DR PRIDE; Q80XZ4; -.
DR ProteomicsDB; 266938; -.
DR Antibodypedia; 15695; 452 antibodies from 35 providers.
DR DNASU; 230828; -.
DR Ensembl; ENSMUST00000102546; ENSMUSP00000099605; ENSMUSG00000037157.
DR GeneID; 230828; -.
DR KEGG; mmu:230828; -.
DR UCSC; uc008vgx.2; mouse.
DR CTD; 58985; -.
DR MGI; MGI:2663588; Il22ra1.
DR VEuPathDB; HostDB:ENSMUSG00000037157; -.
DR eggNOG; ENOG502S4IS; Eukaryota.
DR GeneTree; ENSGT00940000161366; -.
DR HOGENOM; CLU_033634_0_0_1; -.
DR InParanoid; Q80XZ4; -.
DR OMA; CQQITRK; -.
DR OrthoDB; 1078220at2759; -.
DR PhylomeDB; Q80XZ4; -.
DR TreeFam; TF334107; -.
DR Reactome; R-MMU-8854691; Interleukin-20 family signaling.
DR BioGRID-ORCS; 230828; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q80XZ4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80XZ4; protein.
DR Bgee; ENSMUSG00000037157; Expressed in jejunum and 25 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0042015; F:interleukin-20 binding; IPI:MGI.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:MGI.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; SSF49265; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..581
FT /note="Interleukin-22 receptor subunit alpha-1"
FT /id="PRO_0000324321"
FT TOPO_DOM 16..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..581
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 18..115
FT /note="Fibronectin type-III 1"
FT DOMAIN 141..221
FT /note="Fibronectin type-III 2"
FT REGION 343..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 71..79
FT /evidence="ECO:0000250"
FT DISULFID 128..217
FT /evidence="ECO:0000250"
FT CONFLICT 335
FT /note="L -> M (in Ref. 2; BAE24639)"
FT /evidence="ECO:0000305"
FT CONFLICT 535
FT /note="S -> Y (in Ref. 2; BAE24639)"
FT /evidence="ECO:0000305"
FT STRAND 26..33
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 36..42
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 52..59
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 72..80
FT /evidence="ECO:0007829|PDB:6WEO"
FT HELIX 83..85
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 92..100
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 103..109
FT /evidence="ECO:0007829|PDB:6WEO"
FT HELIX 115..118
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 125..130
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 132..140
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 143..147
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 153..155
FT /evidence="ECO:0007829|PDB:6WEO"
FT HELIX 156..159
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 164..172
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 175..190
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 196..205
FT /evidence="ECO:0007829|PDB:6WEO"
FT TURN 206..209
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 215..220
FT /evidence="ECO:0007829|PDB:6WEO"
SQ SEQUENCE 581 AA; 63795 MW; A2BF8692BB8AA93B CRC64;
MKTLLTILTV GSLAAHTTVD TSGLLQHVKF QSSNFENILT WDGGPASTSD TVYSVEYKKY
GERKWLAKAG CQRITQKFCN LTMETRNHTE FYYAKVTAVS AGGPPVTKMT DRFSSLQHTT
IKPPDVTCIP KVRSIQMLVH PTLTPVLSED GHQLTLEEIF HDLFYRLELH VNHTYQMHLE
GKQREYEFLG LTPDTEFLGS ITILTPILSK ESAPYVCRVK TLPDRTWAYS FSGAVLFSMG
FLVGLLCYLG YKYITKPPVP PNSLNVQRVL TFQPLRFIQE HVLIPVLDLS GPSSLPQPIQ
YSQVVVSGPR EPPGAVWRQS LSDLTYVGQS DVSILQPTNV PAQQTLSPPS YAPKAVPEVQ
PPSYAPQVAS DAKALFYSPQ QGMKTRPATY DPQDILDSCP ASYAVCVEDS GKDSTPGILS
TPKYLKTKGQ LQEDTLVRSC LPGDLSLQKV TSLGEGETQR PKSLPSPLGF CTDRGPDLHT
LRSEEPETPR YLKGALSLLS SVQIEGHPVS LPLHVHSVSC SPSDEGPSPW GLLDSLVCPK
DEGPAVETEA MCPSAAASEL EQSTELDSLF KGLALTVQWE S
