ID   I22R2_RAT               Reviewed;         229 AA.
AC   Q7TNI4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Interleukin-22 receptor subunit alpha-2;
DE            Short=IL-22 receptor subunit alpha-2;
DE            Short=IL-22R-alpha-2;
DE            Short=IL-22RA2;
DE   AltName: Full=Cytokine receptor family type 2, soluble 1;
DE            Short=CRF2-S1;
DE   AltName: Full=Interleukin-22-binding protein;
DE            Short=IL-22BP;
DE            Short=IL22BP;
DE   Flags: Precursor;
GN   Name=Il22ra2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Spleen;
RX   PubMed=15201862; DOI=10.1038/sj.gene.6364104;
RA   Weiss B., Wolk K., Gruenberg B.H., Volk H.D., Sterry W., Asadullah K.,
RA   Sabat R.;
RT   "Cloning of murine IL-22 receptor alpha 2 and comparison with its human
RT   counterpart.";
RL   Genes Immun. 5:330-336(2004).
CC   -!- FUNCTION: Receptor for IL22. Binds to IL22, prevents interaction with
CC       the functional IL-22R complex and blocks the activity of IL22 (in
CC       vitro). May play an important role as an IL22 antagonist in the
CC       regulation of inflammatory responses.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AJ555485; CAD88475.1; -; mRNA.
DR   RefSeq; NP_001003404.1; NM_001003404.1.
DR   RefSeq; XP_017445017.1; XM_017589528.1.
DR   RefSeq; XP_017445018.1; XM_017589529.1.
DR   AlphaFoldDB; Q7TNI4; -.
DR   SMR; Q7TNI4; -.
DR   STRING; 10116.ENSRNOP00000016354; -.
DR   GlyGen; Q7TNI4; 1 site.
DR   PaxDb; Q7TNI4; -.
DR   GeneID; 444986; -.
DR   KEGG; rno:444986; -.
DR   UCSC; RGD:1303169; rat.
DR   CTD; 116379; -.
DR   RGD; 1303169; Il22ra2.
DR   VEuPathDB; HostDB:ENSRNOG00000012259; -.
DR   eggNOG; ENOG502S2NT; Eukaryota.
DR   HOGENOM; CLU_081158_1_0_1; -.
DR   InParanoid; Q7TNI4; -.
DR   OMA; SMENYYE; -.
DR   OrthoDB; 1078220at2759; -.
DR   PhylomeDB; Q7TNI4; -.
DR   TreeFam; TF332537; -.
DR   PRO; PR:Q7TNI4; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000012259; Expressed in spleen and 9 other tissues.
DR   Genevisible; Q7TNI4; RN.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR   GO; GO:0042017; F:interleukin-22 binding; ISO:RGD.
DR   GO; GO:0042018; F:interleukin-22 receptor activity; ISO:RGD.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
DR   GO; GO:0042509; P:regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR   Pfam; PF09294; Interfer-bind; 1.
DR   Pfam; PF01108; Tissue_fac; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   PROSITE; PS50853; FN3; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Receptor; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..229
FT                   /note="Interleukin-22 receptor subunit alpha-2"
FT                   /id="PRO_0000011018"
FT   DOMAIN          28..127
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          128..229
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   SITE            65
FT                   /note="Critical for IL22-binding"
FT                   /evidence="ECO:0000250"
FT   SITE            117
FT                   /note="Critical for IL22-binding"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        204..225
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   229 AA;  26722 MW;  5CFFD37652A99365 CRC64;
     MPKHCFLGLL IMLLTTATET QPAHVSLKPQ KVQFQSRNFH NILHWQPGNS LTSNGSVYFV
     QYKTYGQGQW KDKNDCWGTT ALFCDLTKET LDPYEPYYGR VMMAWAGSYS EWTRTPRFTP
     WWETKLDPPV VTITRVNASL RVRLRPPELP HRNQTGKNTS MENYYNLVYR VSIINNSLEK
     EQKAYEGTQR AVEIQGLTPH CSYCVVAEMY QPMFDRRSPR SKERCVQIP