I27L2_BOVIN
ID I27L2_BOVIN Reviewed; 133 AA.
AC Q24JY7; Q6IED3;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Interferon alpha-inducible protein 27-like protein 2 {ECO:0000305};
DE AltName: Full=Interferon-stimulated gene 12b protein {ECO:0000303|PubMed:14728724};
DE Short=ISG12(b) {ECO:0000303|PubMed:14728724};
GN Name=IFI27L2 {ECO:0000250|UniProtKB:Q9H2X8}; Synonyms=FAM14A;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14728724; DOI=10.1186/1471-2164-5-8;
RA Parker N., Porter A.C.G.;
RT "Identification of a novel gene family that includes the interferon-
RT inducible human genes 6-16 and ISG12.";
RL BMC Genomics 5:8-8(2004).
CC -!- FUNCTION: Plays a role in the apoptotic process and has a pro-apoptotic
CC activity. {ECO:0000250|UniProtKB:Q9H2X8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000250|UniProtKB:Q9H2X8}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the IFI6/IFI27 family. {ECO:0000305}.
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DR EMBL; BC114186; AAI14187.1; -; mRNA.
DR EMBL; BN000215; CAE00382.1; -; mRNA.
DR RefSeq; NP_001069529.1; NM_001076061.2.
DR AlphaFoldDB; Q24JY7; -.
DR STRING; 9913.ENSBTAP00000004098; -.
DR PaxDb; Q24JY7; -.
DR PRIDE; Q24JY7; -.
DR Ensembl; ENSBTAT00000004098; ENSBTAP00000004098; ENSBTAG00000003155.
DR GeneID; 535465; -.
DR KEGG; bta:535465; -.
DR CTD; 83982; -.
DR VEuPathDB; HostDB:ENSBTAG00000003155; -.
DR eggNOG; ENOG502S85T; Eukaryota.
DR GeneTree; ENSGT00940000155018; -.
DR HOGENOM; CLU_142338_0_0_1; -.
DR InParanoid; Q24JY7; -.
DR TreeFam; TF340510; -.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000003155; Expressed in anterior segment of eyeball and 102 other tissues.
DR ExpressionAtlas; Q24JY7; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR Gene3D; 6.10.110.10; -; 1.
DR InterPro; IPR009311; IFI6/IFI27-like.
DR InterPro; IPR038213; IFI6/IFI27-like_sf.
DR PANTHER; PTHR16932; PTHR16932; 1.
DR Pfam; PF06140; Ifi-6-16; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..133
FT /note="Interferon alpha-inducible protein 27-like protein
FT 2"
FT /id="PRO_0000247471"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 93..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 133 AA; 12398 MW; 43E591E76AFEB14A CRC64;
MIKRAAAAAI GGALAVAAVP AVLGAVGFTG AGIAASSLAA KMMSAAAVAN GGGVAAGSLV
ATLQSVGAAG LSTSSNILLG SIGSAFGALL GGAKRASPSP PPGGPRPEGE QPGENVPQVE
PPKSPLGPEK HEK
