I27L2_HUMAN
ID I27L2_HUMAN Reviewed; 130 AA.
AC Q9H2X8; Q8TBD7; Q9NYL0;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Interferon alpha-inducible protein 27-like protein 2 {ECO:0000305};
DE AltName: Full=Interferon-stimulated gene 12b protein {ECO:0000303|PubMed:14728724};
DE Short=ISG12(b) {ECO:0000303|PubMed:14728724};
DE Short=ISG12B {ECO:0000303|PubMed:27673746};
DE AltName: Full=Protein TLH29 {ECO:0000312|EMBL:AAG35730.1};
DE AltName: Full=pIFI27-like protein;
GN Name=IFI27L2 {ECO:0000312|HGNC:HGNC:19753};
GN Synonyms=FAM14A {ECO:0000312|HGNC:HGNC:19753},
GN TLH29 {ECO:0000312|EMBL:AAG35730.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hepatoma;
RA Yu S., Chen W.;
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 38-130.
RA Johnsen S.A., Subramaniam M., Spelsberg T.C.;
RT "Identification of a novel homologue of interferon inducible p27.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION, AND INDUCTION BY INTERFERON.
RX PubMed=14728724; DOI=10.1186/1471-2164-5-8;
RA Parker N., Porter A.C.G.;
RT "Identification of a novel gene family that includes the interferon-
RT inducible human genes 6-16 and ISG12.";
RL BMC Genomics 5:8-8(2004).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=27673746; DOI=10.1111/boc.201600034;
RA Gytz H., Hansen M.F., Skovbjerg S., Kristensen A.C., Hoerlyck S.,
RA Jensen M.B., Fredborg M., Markert L.D., McMillan N.A., Christensen E.I.,
RA Martensen P.M.;
RT "Apoptotic properties of the type 1 interferon induced family of human
RT mitochondrial membrane ISG12 proteins.";
RL Biol. Cell 109:94-112(2017).
RN [6]
RP INDUCTION BY INTERFERON.
RX PubMed=27777077; DOI=10.1016/j.virusres.2016.10.013;
RA Chen Y., Jiao B., Yao M., Shi X., Zheng Z., Li S., Chen L.;
RT "ISG12a inhibits HCV replication and potentiates the anti-HCV activity of
RT IFN-alpha through activation of the Jak/STAT signaling pathway independent
RT of autophagy and apoptosis.";
RL Virus Res. 227:231-239(2017).
CC -!- FUNCTION: Plays a role in the apoptotic process and has a pro-apoptotic
CC activity. {ECO:0000269|PubMed:27673746}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:27673746}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- INDUCTION: Not up-regulated by type-I interferon.
CC {ECO:0000269|PubMed:14728724, ECO:0000269|PubMed:27777077}.
CC -!- SIMILARITY: Belongs to the IFI6/IFI27 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF65760.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF208232; AAG35730.1; -; mRNA.
DR EMBL; BC022800; AAH22800.2; -; mRNA.
DR EMBL; BC032626; AAH32626.1; -; mRNA.
DR EMBL; AF238978; AAF65760.1; ALT_FRAME; mRNA.
DR EMBL; BN000226; CAE00393.1; -; mRNA.
DR CCDS; CCDS9920.1; -.
DR RefSeq; NP_114425.1; NM_032036.2.
DR AlphaFoldDB; Q9H2X8; -.
DR IntAct; Q9H2X8; 5.
DR STRING; 9606.ENSP00000238609; -.
DR BioMuta; IFI27L2; -.
DR DMDM; 27805468; -.
DR EPD; Q9H2X8; -.
DR jPOST; Q9H2X8; -.
DR MassIVE; Q9H2X8; -.
DR MaxQB; Q9H2X8; -.
DR PaxDb; Q9H2X8; -.
DR PeptideAtlas; Q9H2X8; -.
DR PRIDE; Q9H2X8; -.
DR ProteomicsDB; 80631; -.
DR TopDownProteomics; Q9H2X8; -.
DR Antibodypedia; 27013; 79 antibodies from 16 providers.
DR DNASU; 83982; -.
DR Ensembl; ENST00000238609.4; ENSP00000238609.3; ENSG00000119632.4.
DR Ensembl; ENST00000619362.2; ENSP00000482521.1; ENSG00000276879.2.
DR GeneID; 83982; -.
DR KEGG; hsa:83982; -.
DR MANE-Select; ENST00000238609.4; ENSP00000238609.3; NM_032036.3; NP_114425.1.
DR UCSC; uc001ycq.4; human.
DR CTD; 83982; -.
DR GeneCards; IFI27L2; -.
DR HGNC; HGNC:19753; IFI27L2.
DR HPA; ENSG00000119632; Low tissue specificity.
DR MIM; 611319; gene.
DR neXtProt; NX_Q9H2X8; -.
DR OpenTargets; ENSG00000119632; -.
DR PharmGKB; PA164720861; -.
DR VEuPathDB; HostDB:ENSG00000119632; -.
DR eggNOG; ENOG502S85T; Eukaryota.
DR GeneTree; ENSGT00940000155018; -.
DR InParanoid; Q9H2X8; -.
DR OMA; APLAIWG; -.
DR OrthoDB; 1586557at2759; -.
DR PhylomeDB; Q9H2X8; -.
DR TreeFam; TF340510; -.
DR PathwayCommons; Q9H2X8; -.
DR SignaLink; Q9H2X8; -.
DR BioGRID-ORCS; 83982; 11 hits in 1076 CRISPR screens.
DR ChiTaRS; IFI27L2; human.
DR GenomeRNAi; 83982; -.
DR Pharos; Q9H2X8; Tdark.
DR PRO; PR:Q9H2X8; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9H2X8; protein.
DR Bgee; ENSG00000119632; Expressed in C1 segment of cervical spinal cord and 96 other tissues.
DR ExpressionAtlas; Q9H2X8; baseline and differential.
DR Genevisible; Q9H2X8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IMP:UniProtKB.
DR GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR Gene3D; 6.10.110.10; -; 1.
DR InterPro; IPR009311; IFI6/IFI27-like.
DR InterPro; IPR038213; IFI6/IFI27-like_sf.
DR PANTHER; PTHR16932; PTHR16932; 1.
DR Pfam; PF06140; Ifi-6-16; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..130
FT /note="Interferon alpha-inducible protein 27-like protein
FT 2"
FT /id="PRO_0000008740"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 93..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 130 AA; 12410 MW; C7283B34AE64CD87 CRC64;
MMKRAAAAAV GGALAVGAVP VVLSAMGFTG AGIAASSIAA KMMSAAAIAN GGGVSAGSLV
ATLQSVGAAG LSTSSNILLA SVGSVLGACL GNSPSSSLPA EPEAKEDEAR ENVPQGEPPK
PPLKSEKHEE
