ID   I2B1_CONFR              Reviewed;          74 AA.
AC   P0DKM1;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Conotoxin fe11.1;
DE   Flags: Precursor;
OS   Conus ferrugineus (Cone snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX   NCBI_TaxID=379542;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16477526; DOI=10.1007/s00239-005-0010-x;
RA   Watkins M., Hillyard D.R., Olivera B.M.;
RT   "Genes expressed in a turrid venom duct: divergence and similarity to
RT   conotoxins.";
RL   J. Mol. Evol. 62:247-256(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
CC   -!- CAUTION: This sequence has been copied from a figure, and no
CC       information except the name are available for it. The species, and the
CC       sequence origin are only deduced to be C.ferrugineus and nucleotide
CC       sequence. {ECO:0000305}.
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DR   AlphaFoldDB; P0DKM1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR020242; Conotoxin_I2-superfamily.
DR   Pfam; PF17557; Conotoxin_I2; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..58
FT                   /note="Conotoxin fe11.1"
FT                   /id="PRO_0000419832"
FT   PROPEP          62..74
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000419833"
FT   MOD_RES         58
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        28..42
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        35..47
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        41..51
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        46..55
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   74 AA;  8232 MW;  8FE7FB37A01A6C75 CRC64;
     MMFRVTSVGC FLLVIVLLHV AAVTSDDCRP EAAYCEYNEQ CCIDKCCQAS CSDACRTPGK
     RVHGHGLLRF FGQR