ID   I2B1_CONLT              Reviewed;          63 AA.
AC   C7DQC1;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Conotoxin Lt11.1 {ECO:0000303|PubMed:19595726};
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=19595726; DOI=10.1016/j.peptides.2009.06.036;
RA   Liu Z., Xu N., Hu J., Zhao C., Yu Z., Dai Q.;
RT   "Identification of novel I-superfamily conopeptides from several clades of
RT   Conus species found in the South China Sea.";
RL   Peptides 30:1782-1787(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19595726}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:19595726}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GQ180869; ACU30731.1; -; mRNA.
DR   AlphaFoldDB; C7DQC1; -.
DR   PRIDE; C7DQC1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         24..50
FT                   /note="Conotoxin Lt11.1"
FT                   /id="PRO_0000392051"
FT   PROPEP          53..63
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392052"
FT   DISULFID        24..34
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        28..39
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        33..42
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        38..47
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   63 AA;  7094 MW;  E48C88E82DDFAE0D CRC64;
     MMFRLTSVLL VIVLLNLVVL TNACHMDCSK MICCSGICCF YCGLPSCDDT RRALLQRLLG
     HQR