ID   I2B2A_DANRE             Reviewed;         491 AA.
AC   Q6NZT6; B8JMF1; Q7ZV30;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Interferon regulatory factor 2-binding protein 2-A;
DE            Short=IRF-2-binding protein 2-A;
DE            Short=IRF-2BP2-A;
GN   Name=irf2bp2a; ORFNames=si:ch1073-404g22.1, zgc:56251;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRF2BP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAX13278.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR854915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU633825; CAX13278.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC046025; AAH46025.1; -; mRNA.
DR   EMBL; BC065975; AAH65975.1; -; mRNA.
DR   RefSeq; NP_956275.1; NM_199981.1.
DR   AlphaFoldDB; Q6NZT6; -.
DR   SMR; Q6NZT6; -.
DR   STRING; 7955.ENSDARP00000117801; -.
DR   PaxDb; Q6NZT6; -.
DR   PRIDE; Q6NZT6; -.
DR   GeneID; 335866; -.
DR   KEGG; dre:335866; -.
DR   CTD; 335866; -.
DR   ZFIN; ZDB-GENE-030131-7809; irf2bp2a.
DR   eggNOG; KOG3579; Eukaryota.
DR   InParanoid; Q6NZT6; -.
DR   OrthoDB; 1156771at2759; -.
DR   PhylomeDB; Q6NZT6; -.
DR   TreeFam; TF317075; -.
DR   PRO; PR:Q6NZT6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1580; -; 1.
DR   InterPro; IPR044882; I2BP1/2_C3HC4-RING_sf.
DR   InterPro; IPR022750; Interferon_reg_fac2-bd1_2_Znf.
DR   Pfam; PF11261; IRF-2BP1_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..491
FT                   /note="Interferon regulatory factor 2-binding protein 2-A"
FT                   /id="PRO_0000328736"
FT   ZN_FING         410..457
FT                   /note="RING-type; degenerate"
FT   REGION          60..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          410..457
FT                   /note="Cys-rich"
FT   COMPBIAS        183..213
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..315
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..378
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        9
FT                   /note="S -> P (in Ref. 2; AAH46025)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        239
FT                   /note="Q -> H (in Ref. 2; AAH46025)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   491 AA;  52888 MW;  06A716862C8BE2FE CRC64;
     MSSAAVAASR RQSCYLCDLP RMPWAMIWDF TEPVCRGCVN YEGADRIEFV IETARQLKRA
     HGFQDGRPAG PGKQLPGKEI HASGDPGSRP PQPLDRYPLS SERPPRLGAE YQSARQANGI
     PVPNGFSKPD DPPELNRQSP NPRRTSGVPP NLVPLVNGSM AHAMNGRPGQ MSDLGGNKRP
     ASVSSTEHDK DKHRPDSLTP EISDGHKTRA DDWLNKNKTV RELMTLNPYD GRFKKEHMQQ
     RVMYETGPAS KSDRGKHPKN LKRKASPEPD GEGTAGKING DGQQWLPSAS GDGLKMPPVP
     PPSFTSPPST ISPHPRTTPP EAGAAAAATQ NGHSPIAALI LAADNAGGNS SPKDANQVHS
     TTRRNSNSPL SPNQRRLAQG AGTPHVPGMD AVHPQSIPDS SVPSSIPLCC TLCHERLEDT
     HFVQCPSVPS HKFCFPCSRE SIKQQGATGE VYCPSGEKCP LVGSNVPWAF MQGEIATILA
     GDVKVKKERD P