I2B2_CONSR
ID I2B2_CONSR Reviewed; 70 AA.
AC P0C258;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Kappa-conotoxin-like Sx11.2;
DE Flags: Precursor;
OS Conus striolatus (Cone snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX NCBI_TaxID=101315;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=16098199; DOI=10.1111/j.1742-4658.2005.04830.x;
RA Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RT "Characterization of D-amino-acid-containing excitatory conotoxins and
RT redefinition of the I-conotoxin superfamily.";
RL FEBS J. 272:4178-4188(2005).
RN [2]
RP ERRATUM OF PUBMED:16098199.
RA Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RL FEBS J. 272:4839-4839(2005).
CC -!- FUNCTION: Modulator of potassium channels, specifically up-modulates
CC the calcium and voltage-gated BK channels, has no effect on single
CC channel conductance, but increases the open probability of BK channels.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C258; -.
DR SMR; P0C258; -.
DR ConoServer; 1452; Sx11.2 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR013141; Conotoxin-I_CS.
DR InterPro; IPR020242; Conotoxin_I2-superfamily.
DR Pfam; PF17557; Conotoxin_I2; 1.
DR PROSITE; PS60019; I_CONOTOXIN; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Disulfide bond;
KW Gamma-carboxyglutamic acid; Hydroxylation; Ion channel impairing toxin;
KW Neurotoxin; Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..57
FT /note="Kappa-conotoxin-like Sx11.2"
FT /id="PRO_0000262687"
FT PROPEP 61..70
FT /id="PRO_0000262688"
FT MOD_RES 30
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000250"
FT MOD_RES 35
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000250"
FT MOD_RES 44
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000250"
FT MOD_RES 53
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 57
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT DISULFID 27..41
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 34..46
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 40..50
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT DISULFID 45..54
FT /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ SEQUENCE 70 AA; 7900 MW; F6575A2E830AD903 CRC64;
MMFRVTSVGC LLLVIVFLNL VVPTSACRAE GTYCENDSQC CLNECCWGGC GHPCRHPGKR
SKLQEFFRQR