ID   I2B3_CONIM              Reviewed;          84 AA.
AC   C7DQY0;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Kappa-conotoxin-like Im11.3 {ECO:0000303|PubMed:19595726};
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=19595726; DOI=10.1016/j.peptides.2009.06.036;
RA   Liu Z., Xu N., Hu J., Zhao C., Yu Z., Dai Q.;
RT   "Identification of novel I-superfamily conopeptides from several clades of
RT   Conus species found in the South China Sea.";
RL   Peptides 30:1782-1787(2009).
CC   -!- FUNCTION: Inhibits the vertebrate voltage-gated potassium channels
CC       Kv1.1/KCNA1 and Kv1.3/KCNA3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19595726}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:19595726}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
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DR   EMBL; GQ184580; ACU30737.2; -; mRNA.
DR   AlphaFoldDB; C7DQY0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         27..70
FT                   /note="Kappa-conotoxin-like Im11.3"
FT                   /id="PRO_0000392055"
FT   PROPEP          71..84
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392056"
FT   DISULFID        29..43
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        36..48
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        42..51
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        47..64
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   84 AA;  9627 MW;  B10DEBA8480ADB9D CRC64;
     MMFRLTSVSC FLLVIACLNL FQVVLTSRCF PPGIYCTPYL PCCWGICCGT CRNDNSSLTF
     LQFCLPFFFF LRPSHPLFLL LPAR