ID   I2B8_CONEM              Reviewed;          67 AA.
AC   C7DQB7;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Kappa-conotoxin-like Em11.8 {ECO:0000303|PubMed:19595726};
DE   Flags: Precursor;
OS   Conus emaciatus (False virgin cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virgiconus.
OX   NCBI_TaxID=89442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=19595726; DOI=10.1016/j.peptides.2009.06.036;
RA   Liu Z., Xu N., Hu J., Zhao C., Yu Z., Dai Q.;
RT   "Identification of novel I-superfamily conopeptides from several clades of
RT   Conus species found in the South China Sea.";
RL   Peptides 30:1782-1787(2009).
CC   -!- FUNCTION: Inhibits the vertebrate voltage-gated potassium channels
CC       Kv1.1/KCNA1 and Kv1.3/KCNA3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19595726}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:19595726}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
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DR   EMBL; GQ180865; ACU30727.1; -; mRNA.
DR   AlphaFoldDB; C7DQB7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR020242; Conotoxin_I2-superfamily.
DR   Pfam; PF17557; Conotoxin_I2; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin; Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         27..59
FT                   /note="Kappa-conotoxin-like Em11.8"
FT                   /id="PRO_0000392049"
FT   PROPEP          63..67
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392050"
FT   MOD_RES         59
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        29..43
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        36..48
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        42..51
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        47..55
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   67 AA;  7633 MW;  4A941D012446F62D CRC64;
     MMFRLTSVSC FLLVIACLNL FQVVLTSRCF PPGIYCTPYL PCCWGICCGT CRNVCHLRFG
     KRATFQE