ID   I2BA_CONEM              Reviewed;          39 AA.
AC   P0C252;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Kappa-conotoxin-like Em11.10;
DE   Flags: Precursor; Fragment;
OS   Conus emaciatus (False virgin cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virgiconus.
OX   NCBI_TaxID=89442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16098199; DOI=10.1111/j.1742-4658.2005.04830.x;
RA   Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RT   "Characterization of D-amino-acid-containing excitatory conotoxins and
RT   redefinition of the I-conotoxin superfamily.";
RL   FEBS J. 272:4178-4188(2005).
RN   [2]
RP   ERRATUM OF PUBMED:16098199.
RA   Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., Olivera B.M.;
RL   FEBS J. 272:4839-4839(2005).
CC   -!- FUNCTION: Inhibits the vertebrate voltage-gated potassium channels
CC       Kv1.1/KCNA1 and Kv1.3/KCNA3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0C252; -.
DR   SMR; P0C252; -.
DR   ConoServer; 1457; Em11.10 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR020242; Conotoxin_I2-superfamily.
DR   Pfam; PF17557; Conotoxin_I2; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Toxin; Voltage-gated potassium channel impairing toxin.
FT   CHAIN           <1..31
FT                   /note="Kappa-conotoxin-like Em11.10"
FT                   /id="PRO_0000262675"
FT   PROPEP          35..39
FT                   /id="PRO_0000262676"
FT   MOD_RES         31
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        1..15
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        8..20
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        14..23
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        19..27
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   NON_TER         1
SQ   SEQUENCE   39 AA;  4411 MW;  88DBA91414122051 CRC64;
     CFPPGIYCTP YLPCCWGICC GTCRNVCHLR IGKRATFQE