ID   I2BB_CONIM              Reviewed;          70 AA.
AC   A0A125S9E2;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Conotoxin Im11.11 {ECO:0000305};
DE   AltName: Full=Conopeptide im008 {ECO:0000303|PubMed:30893765, ECO:0000312|EMBL:AME17666.1};
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30893765; DOI=10.3390/md17030177;
RA   Jin A.H., Dutertre S., Dutt M., Lavergne V., Jones A., Lewis R.J.,
RA   Alewood P.F.;
RT   "Transcriptomic-proteomic correlation in the predation-evoked venom of the
RT   cone snail, Conus imperialis.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30893765}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30893765}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}.
CC   -!- MISCELLANEOUS: The mature protein is identical to the Conus litteratus
CC       toxin AC C7DQX6. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
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DR   EMBL; KT377402; AME17666.1; -; mRNA.
DR   AlphaFoldDB; A0A125S9E2; -.
DR   SMR; A0A125S9E2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR020242; Conotoxin_I2-superfamily.
DR   Pfam; PF17557; Conotoxin_I2; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..56
FT                   /note="Conotoxin Im11.11"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5007179685"
FT   PROPEP          60..70
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000450999"
FT   MOD_RES         56
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000305"
FT   DISULFID        26..40
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        33..45
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        39..49
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        44..53
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   70 AA;  7873 MW;  4F88525B6EC079E9 CRC64;
     MFRLTSVGCI LLVIAFLNLV GLTNACTSEG YSCSSDSNCC KNVCCWNVCE SHCRHPGKRT
     RLQGFFKHRR