ID   I2BP1_DANRE             Reviewed;         605 AA.
AC   Q1LV17; A4IG01;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Interferon regulatory factor 2-binding protein 1;
DE            Short=IRF-2-binding protein 1;
DE            Short=IRF-2BP1;
GN   Name=irf2bp1; ORFNames=si:dkey-223n17.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRF2BP family. {ECO:0000305}.
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DR   EMBL; BX908751; CAK05477.1; -; Genomic_DNA.
DR   EMBL; BC134860; AAI34861.1; -; mRNA.
DR   RefSeq; NP_001037819.2; NM_001044354.2.
DR   AlphaFoldDB; Q1LV17; -.
DR   SMR; Q1LV17; -.
DR   STRING; 7955.ENSDARP00000026919; -.
DR   PaxDb; Q1LV17; -.
DR   Ensembl; ENSDART00000018163; ENSDARP00000026919; ENSDARG00000005468.
DR   GeneID; 556852; -.
DR   KEGG; dre:556852; -.
DR   CTD; 26145; -.
DR   ZFIN; ZDB-GENE-050420-389; irf2bp1.
DR   eggNOG; KOG3579; Eukaryota.
DR   GeneTree; ENSGT00940000162120; -.
DR   HOGENOM; CLU_019307_2_0_1; -.
DR   InParanoid; Q1LV17; -.
DR   OMA; VEYPCGS; -.
DR   OrthoDB; 1156771at2759; -.
DR   PhylomeDB; Q1LV17; -.
DR   TreeFam; TF317075; -.
DR   PRO; PR:Q1LV17; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 18.
DR   Bgee; ENSDARG00000005468; Expressed in heart and 27 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1580; -; 1.
DR   InterPro; IPR044882; I2BP1/2_C3HC4-RING_sf.
DR   InterPro; IPR022750; Interferon_reg_fac2-bd1_2_Znf.
DR   Pfam; PF11261; IRF-2BP1_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..605
FT                   /note="Interferon regulatory factor 2-binding protein 1"
FT                   /id="PRO_0000328731"
FT   REGION          61..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          524..571
FT                   /note="Cys-rich"
FT   COILED          200..229
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        88..102
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..400
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..480
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..503
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        197
FT                   /note="M -> I (in Ref. 2; AAI34861)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   605 AA;  64906 MW;  66DE3B6F02848C90 CRC64;
     MSSSSQASSR RQWCYLCDLP KMPWAMIWDF SEAVCRGCVN YEGADRIELL IDTARQLKRT
     HVMQDGRSPG PQPGGKHGPA GKEGPMEAGR PPSERYERGR GEYVSARLPN GLPRLEDGGP
     PEVSRQSPTA RRTLVGAVPP NLMAQGLVGA PHGLLTAMPL NPRAGSAALT IPAPMLNEIS
     KRQALSMGLS VGVPSFMAPE FEKEFKEKQR NAEALAELSE SVRNRADDWA GRPKPMRDAL
     HTLSGCTPFN VRFKKDHGLV GRVFAFDAKL MVEFELKIFI EYPCGSGNVF PSILALVKHM
     FHDSQKDTGK VINSGYKYVE YEKRHGTGDW RLLSELLSDA VRAFKEMPAP DALPQPYLDA
     SCSMLPTALC HIGRPTQPRV RRRKASPDPD GAERMSSEEL RQHWPLSAYP GIPGHMPATS
     LASAGQAPEG HGSDPSPITA LMSVADNVGT ASSKDGPGSS GHSANAGRQN STSPSPGGGQ
     RRLASRNGEP SAGSSTGGPA TVTDQSAVMG GEGSAGGGGA PLCCTICQER LEDTHFVQCP
     SVAGHKFCFP CTRDFIRRQG PGSEVYCPSG EKCPLVGSNV PWAFMQGEIS TILAGDVKVK
     KERDP