ID   I2BP2_XENLA             Reviewed;         537 AA.
AC   Q7ZXS3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Interferon regulatory factor 2-binding protein 2;
DE            Short=IRF-2-binding protein 2;
DE            Short=IRF-2BP2;
GN   Name=irf2bp2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRF2BP family. {ECO:0000305}.
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DR   EMBL; BC044275; AAH44275.1; -; mRNA.
DR   RefSeq; NP_001080568.1; NM_001087099.1.
DR   AlphaFoldDB; Q7ZXS3; -.
DR   SMR; Q7ZXS3; -.
DR   DNASU; 380260; -.
DR   GeneID; 380260; -.
DR   KEGG; xla:380260; -.
DR   CTD; 380260; -.
DR   OMA; KAEHMSP; -.
DR   OrthoDB; 1156771at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 380260; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1580; -; 1.
DR   InterPro; IPR044882; I2BP1/2_C3HC4-RING_sf.
DR   InterPro; IPR022750; Interferon_reg_fac2-bd1_2_Znf.
DR   Pfam; PF11261; IRF-2BP1_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..537
FT                   /note="Interferon regulatory factor 2-binding protein 2"
FT                   /id="PRO_0000328737"
FT   ZN_FING         456..503
FT                   /note="RING-type; degenerate"
FT   REGION          60..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          268..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          456..503
FT                   /note="Cys-rich"
FT   COMPBIAS        68..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..254
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..446
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   537 AA;  57244 MW;  DFE8611B462AF728 CRC64;
     MSSATVAASR RQSCYLCDLP RMPWAMIWDF TEPVCRGCVN YEGADRIEFV IETARHLKRA
     HGFQEGRSPG PSPSSSSSSS SSSSVKPQLS AKEMAQIGHT MGGPEGVTRT SQQPPPPQCL
     DRYSLERPPP PRLGSEYGLG RQVNGILLPN GFPKPEEPPE LNRQSPNPRR TSTVPQSLGA
     LMNGTPMGSA RATIGLSGAS LVAAAAATTS ADLSGKRPGS VSSSEHDGKE KHRADSYSEL
     GENHKSRAEE WISKPKTVRD TLMAMQHSHS PFDSKFKKDT GPGRVLSFEA NNPVSKSGAR
     GGRKRKTSPE PEGEGGSVKI NGEGQPWLPA TESLKISTMA SPSFISPPST VSPHSNRTTP
     PEAAQNGQSP MAALILVADN AGGNHASKDA NQVHSTTRRN SSSPPSPSSM NQRRMAPRDV
     PSQLPSGGTS SHAGMEQGLP QSIPDSSIPN SIPLCCTLCH ERLEDTHFVQ CPSVPSHKFC
     FPCSRQSIKQ QGSSGEVYCP SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS