ID   I2BP2_XENTR             Reviewed;         537 AA.
AC   Q6DIH5; Q6P3P8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Interferon regulatory factor 2-binding protein 2;
DE            Short=IRF-2-binding protein 2;
DE            Short=IRF-2BP2;
GN   Name=irf2bp2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRF2BP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH63909.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC075565; AAH75565.1; -; mRNA.
DR   EMBL; BC063909; AAH63909.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001001988.1; NM_001001988.1.
DR   AlphaFoldDB; Q6DIH5; -.
DR   SMR; Q6DIH5; -.
DR   STRING; 8364.ENSXETP00000053106; -.
DR   PaxDb; Q6DIH5; -.
DR   DNASU; 394851; -.
DR   Ensembl; ENSXETT00000053106; ENSXETP00000053106; ENSXETG00000024649.
DR   GeneID; 394851; -.
DR   KEGG; xtr:394851; -.
DR   CTD; 359948; -.
DR   Xenbase; XB-GENE-1015579; irf2bp2.
DR   eggNOG; KOG3579; Eukaryota.
DR   HOGENOM; CLU_019307_2_0_1; -.
DR   InParanoid; Q6DIH5; -.
DR   OrthoDB; 1156771at2759; -.
DR   PhylomeDB; Q6DIH5; -.
DR   TreeFam; TF317075; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000024649; Expressed in early embryo and 21 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1580; -; 1.
DR   InterPro; IPR044882; I2BP1/2_C3HC4-RING_sf.
DR   InterPro; IPR022750; Interferon_reg_fac2-bd1_2_Znf.
DR   Pfam; PF11261; IRF-2BP1_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..537
FT                   /note="Interferon regulatory factor 2-binding protein 2"
FT                   /id="PRO_0000328738"
FT   ZN_FING         456..503
FT                   /note="RING-type; degenerate"
FT   REGION          60..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          208..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          456..503
FT                   /note="Cys-rich"
FT   COMPBIAS        68..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..446
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   537 AA;  57156 MW;  10541A7D927C79AD CRC64;
     MSSATVAASR RQSCYLCDLP RMPWAMIWDF TEPVCRGCVN YEGADRIEFV IETARHLKRA
     HGFQEGRSPG PSPSSSSSSS SSSSVKPQLS AKEMAQIGHT MGGPEGVTRT SQQPPPPQCL
     DRYSLERPPP PRLGSEYGVG RQVNGILLPN GFPKPEEPPE LNRQSPNPRR TSSVPQSLGA
     LMNGAPIGSG RTPVGLSAAS LVAAAAATTS ADLSGKRPGS VSSSEHDGKE KHRADSYSEL
     GENHKSRAEE WISKPKTVRD TLMAMQHSHS PFDSKFKKDP GPGRVLSFEA NNPASKSGAR
     GGRKRKPSPE PEGEGGSVKM NGEGQPWLPA AESLKISTMA SPSFISPPST VSPHSNRTTP
     PEAAQNGQSP MAALILVADN AGGNHASKDA NQVHSTTRRN SSSPPSPSSM NQRRMAPRDV
     PSQIPSGGTS SHAGMEQGHP QSIPDSSIPN SIPLCCTLCH ERLEDTHFVQ CPSVPSHKFC
     FPCSRQSIKQ QGSSGEVYCP SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS