ID   I2B_CONTE               Reviewed;          69 AA.
AC   Q5I4E5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Conotoxin Gla-TxXI;
DE   Flags: Precursor;
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-56,
RP   GAMMA-CARBOXYGLUTAMATION AT GLU-29, AMIDATION AT PRO-56, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=15966739; DOI=10.1021/bi0503293;
RA   Brown M.A., Begley G.S., Czerwiec E., Stenberg L.M., Jacobs M.,
RA   Kalume D.E., Roepstorff P., Stenflo J., Furie B.C., Furie B.;
RT   "Precursors of novel Gla-containing conotoxins contain a carboxy-terminal
RT   recognition site that directs gamma-carboxylation.";
RL   Biochemistry 44:9150-9159(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- PTM: Contains 4 disulfide bonds.
CC   -!- MASS SPECTROMETRY: Mass=3313.4; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15966739};
CC   -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
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DR   EMBL; AY856070; AAW50950.1; -; mRNA.
DR   AlphaFoldDB; Q5I4E5; -.
DR   SMR; Q5I4E5; -.
DR   ConoServer; 1057; TxXI precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR020242; Conotoxin_I2-superfamily.
DR   Pfam; PF17557; Conotoxin_I2; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Gamma-carboxyglutamic acid; Secreted; Signal; Toxin.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..56
FT                   /note="Conotoxin Gla-TxXI"
FT                   /id="PRO_0000262449"
FT   PROPEP          60..69
FT                   /id="PRO_0000262450"
FT   MOD_RES         29
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000269|PubMed:15966739"
FT   MOD_RES         56
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:15966739"
FT   DISULFID        26..40
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        33..45
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        39..49
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        44..53
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   69 AA;  7552 MW;  51BEA105E65A5DEE CRC64;
     MVRVTSVGCF LLVIVSLNLV VLTNACIPEG SSCSSSGSCC HKSCCRWTCN QPCLIPGKRA
     KLLEFFRQR