ID   I2_CONMI                Reviewed;          68 AA.
AC   P69498; Q59AA4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Conotoxin Mi11.1;
DE   Flags: Precursor;
OS   Conus miles (Soldier cone) (Mile cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Rhizoconus.
OX   NCBI_TaxID=69564;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=15450929; DOI=10.1016/j.toxicon.2004.07.006;
RA   Kauferstein S., Huys I., Kuch U., Melaun C., Tytgat J., Mebs D.;
RT   "Novel conopeptides of the I-superfamily occur in several clades of cone
RT   snails.";
RL   Toxicon 44:539-548(2004).
RN   [2]
RP   PREDICTION OF FUNCTION.
RX   PubMed=16835884; DOI=10.1002/psc.778;
RA   Mondal S., Babu R.M., Bhavna R., Ramakumar S.;
RT   "I-conotoxin superfamily revisited.";
RL   J. Pept. Sci. 12:679-685(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
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DR   EMBL; AJ746189; CAG34097.1; -; mRNA.
DR   AlphaFoldDB; P69498; -.
DR   SMR; P69498; -.
DR   PRIDE; P69498; -.
DR   ConoServer; 1084; Mi11.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR020242; Conotoxin_I2-superfamily.
DR   Pfam; PF17557; Conotoxin_I2; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..60
FT                   /note="Conotoxin Mi11.1"
FT                   /id="PRO_0000035096"
FT   PROPEP          64..68
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000035097"
FT   MOD_RES         60
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        29..43
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        36..48
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        42..52
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        47..56
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   CONFLICT        3
FT                   /note="L -> F (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        57
FT                   /note="S -> F (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   68 AA;  7795 MW;  CF4FFBF7186162E3 CRC64;
     MMLRLTSVSC FLLVIACLNL FQVVLTRRCF PPGTFCSRYL PCCSGRCCSG WCTRRCSPRY
     GKRATFQE