ID   I2_CONST                Reviewed;          68 AA.
AC   P69499; Q59AA5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=conotoxin S11.3;
DE   Flags: Precursor;
OS   Conus striatus (Striated cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=6493;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=15450929; DOI=10.1016/j.toxicon.2004.07.006;
RA   Kauferstein S., Huys I., Kuch U., Melaun C., Tytgat J., Mebs D.;
RT   "Novel conopeptides of the I-superfamily occur in several clades of cone
RT   snails.";
RL   Toxicon 44:539-548(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin I2 superfamily. {ECO:0000305}.
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DR   EMBL; AJ746188; CAG34096.1; -; mRNA.
DR   AlphaFoldDB; P69499; -.
DR   SMR; P69499; -.
DR   ConoServer; 1391; S11.3 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013141; Conotoxin-I_CS.
DR   InterPro; IPR020242; Conotoxin_I2-superfamily.
DR   Pfam; PF17557; Conotoxin_I2; 1.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..60
FT                   /note="conotoxin S11.3"
FT                   /id="PRO_0000035114"
FT   PROPEP          64..68
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000035115"
FT   MOD_RES         60
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        29..43
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        36..48
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        42..52
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        47..56
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   68 AA;  7927 MW;  E462E2ACEB3AA4C0 CRC64;
     MMFRLTSVSC FLLVIVCLNL FQVVLTRRCV PPSRYCTRHR PCCRGTCCSG LCRPMCNLWY
     GKRATFQE