ID   I2_VACCC                Reviewed;          73 AA.
AC   P68604; P12922;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   29-SEP-2021, entry version 44.
DE   RecName: Full=Protein I2;
GN   ORFNames=I2L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Late protein which probably plays a role in virus entry into
CC       the host cell. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Note=Component of the membrane of the
CC       mature virion.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I2 family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48057.1; -; Genomic_DNA.
DR   PIR; B29889; WZVZI2.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR009175; Poxvirus_I2.
DR   Pfam; PF12575; Pox_EPC_I2-L1; 1.
DR   PIRSF; PIRSF003766; VAC_I2L; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Viral penetration into host cytoplasm; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..73
FT                   /note="Protein I2"
FT                   /id="PRO_0000099566"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   73 AA;  8499 MW;  9AA89F7883384C72 CRC64;
     MDKLYAAIFG VFMGSPEDDL TDFIEIVKSV LSDEKTVTST NNTGCWGWYW LIIIFFIVLI
     LLLLIYLYLK VVW