ID   I2_VACCP                Reviewed;          73 AA.
AC   P68605; P12922;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   02-JUN-2021, entry version 36.
DE   RecName: Full=Protein I2;
GN   ORFNames=I2L;
OS   Vaccinia virus (strain L-IVP) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=31531;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2250685;
RA   Riazankina O.I., Shchelkunov S.N., Muravlev A.I., Netesova N.A.,
RA   Mikriukov N.N., Gutorov V.V., Nikulin A.E., Kulichkov V.A., Malygin E.G.;
RT   "Molecular-biological study of vaccinia virus genome. II. Localization and
RT   nucleotide sequence of vaccinia virus genes coding for proteins 36K and
RT   12K.";
RL   Mol. Biol. (Mosk.) 24:968-976(1990).
CC   -!- FUNCTION: Late protein which probably plays a role in virus entry into
CC       the host cell. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Note=Component of the membrane of the
CC       mature virion.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I2 family. {ECO:0000305}.
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DR   EMBL; X61165; CAA43474.1; -; Genomic_DNA.
DR   PIR; B29889; WZVZI2.
DR   RefSeq; YP_232953.1; NC_006998.1.
DR   DNASU; 3707604; -.
DR   GeneID; 3707604; -.
DR   KEGG; vg:3707604; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR009175; Poxvirus_I2.
DR   Pfam; PF12575; Pox_EPC_I2-L1; 1.
DR   PIRSF; PIRSF003766; VAC_I2L; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Membrane; Transmembrane; Transmembrane helix;
KW   Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT   CHAIN           1..73
FT                   /note="Protein I2"
FT                   /id="PRO_0000099567"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   73 AA;  8499 MW;  9AA89F7883384C72 CRC64;
     MDKLYAAIFG VFMGSPEDDL TDFIEIVKSV LSDEKTVTST NNTGCWGWYW LIIIFFIVLI
     LLLLIYLYLK VVW