ID   I2_VACCW                Reviewed;          73 AA.
AC   P68606; P12922; Q76ZV1;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   02-JUN-2021, entry version 47.
DE   RecName: Full=Protein I2;
GN   OrderedLocusNames=VACWR071; ORFNames=I2L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2835495; DOI=10.1128/jvi.62.6.1889-1897.1988;
RA   Schmitt J.F.C., Stunnenberg H.G.;
RT   "Sequence and transcriptional analysis of the vaccinia virus HindIII I
RT   fragment.";
RL   J. Virol. 62:1889-1897(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, INDUCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=18701587; DOI=10.1128/jvi.01035-08;
RA   Nichols R.J., Stanitsa E., Unger B., Traktman P.;
RT   "The vaccinia virus gene I2L encodes a membrane protein with an essential
RT   role in virion entry.";
RL   J. Virol. 82:10247-10261(2008).
CC   -!- FUNCTION: Late protein which probably plays a role in virus entry into
CC       the host cell. {ECO:0000269|PubMed:18701587}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Note=Component of the membrane of the
CC       mature virion. {ECO:0000269|PubMed:18701587}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:18701587}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I2 family. {ECO:0000305}.
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DR   EMBL; AY243312; AAO89350.1; -; Genomic_DNA.
DR   EMBL; J03399; AAB59804.1; -; Genomic_DNA.
DR   PIR; B29889; WZVZI2.
DR   RefSeq; YP_232953.1; NC_006998.1.
DR   TCDB; 1.G.11.1.1; the poxvirus cell entry protein complex (pep-c) family.
DR   DNASU; 3707604; -.
DR   GeneID; 3707604; -.
DR   KEGG; vg:3707604; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR009175; Poxvirus_I2.
DR   Pfam; PF12575; Pox_EPC_I2-L1; 1.
DR   PIRSF; PIRSF003766; VAC_I2L; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Viral penetration into host cytoplasm; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..73
FT                   /note="Protein I2"
FT                   /id="PRO_0000099568"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   73 AA;  8499 MW;  9AA89F7883384C72 CRC64;
     MDKLYAAIFG VFMGSPEDDL TDFIEIVKSV LSDEKTVTST NNTGCWGWYW LIIIFFIVLI
     LLLLIYLYLK VVW