ID   I361_CONPL              Reviewed;          83 AA.
AC   D2DGD8;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Conotoxin Pu6.1;
DE   Flags: Precursor;
OS   Conus pulicarius (Flea-bitten cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=93154;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=19428762; DOI=10.1016/j.peptides.2009.01.012;
RA   Yuan D.D., Liu L., Shao X.X., Peng C., Chi C.W., Guo Z.Y.;
RT   "New conotoxins define the novel I3-superfamily.";
RL   Peptides 30:861-865(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19428762}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:19428762}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin I3 superfamily. {ECO:0000305}.
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DR   EMBL; FJ531699; ACU30045.1; -; mRNA.
DR   AlphaFoldDB; D2DGD8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..42
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000392160"
FT   PEPTIDE         43..83
FT                   /note="Conotoxin Pu6.1"
FT                   /id="PRO_0000392161"
FT   DISULFID        43..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..78
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   83 AA;  9023 MW;  9E51092876D27BA9 CRC64;
     MKLVLAIVLI LMLVSLSTGA EESGQEISMV GPPLYIWDPI PPCKQLDEDC GYGYSCCEDL
     SCQPLIEPDT MEITALVCQI ESA