ID   I364_CONLT              Reviewed;          81 AA.
AC   D2DGD9;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Conotoxin Lt6.4;
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=19428762; DOI=10.1016/j.peptides.2009.01.012;
RA   Yuan D.D., Liu L., Shao X.X., Peng C., Chi C.W., Guo Z.Y.;
RT   "New conotoxins define the novel I3-superfamily.";
RL   Peptides 30:861-865(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19428762}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:19428762}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin I3 superfamily. {ECO:0000305}.
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DR   EMBL; FJ531700; ACU30046.1; -; mRNA.
DR   AlphaFoldDB; D2DGD9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..42
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000392162"
FT   PEPTIDE         43..81
FT                   /note="Conotoxin Lt6.4"
FT                   /id="PRO_0000392163"
FT   DISULFID        46..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..80
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   81 AA;  8564 MW;  55D8AF3B2F2A0D4F CRC64;
     MKLVLAIVLI LMFLSLSAGA ETSDNGVSRG GHRPQYWPVT PPSIVCLRSG EDCENNTPCC
     PGLSCRVSAD LATLKLSLAC D