ID   I3BA_CONCB              Reviewed;          80 AA.
AC   D2DGD3;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Conotoxin Ca11a;
DE   AltName: Full=Ca11.1;
DE   Flags: Precursor;
OS   Conus caracteristicus (Characteristic cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 43-80, MASS SPECTROMETRY,
RP   AND SUBCELLULAR LOCATION.
RX   PubMed=19428762; DOI=10.1016/j.peptides.2009.01.012;
RA   Yuan D.D., Liu L., Shao X.X., Peng C., Chi C.W., Guo Z.Y.;
RT   "New conotoxins define the novel I3-superfamily.";
RL   Peptides 30:861-865(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19428762}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:19428762}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=4000; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:19428762};
CC   -!- SIMILARITY: Belongs to the conotoxin I3 superfamily. {ECO:0000305}.
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DR   EMBL; FJ531694; ACU30040.1; -; mRNA.
DR   AlphaFoldDB; D2DGD3; -.
DR   SMR; D2DGD3; -.
DR   TCDB; 8.B.16.4.2; the maurocalcine (maca) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..42
FT                   /evidence="ECO:0000269|PubMed:19428762"
FT                   /id="PRO_0000392150"
FT   PEPTIDE         43..80
FT                   /note="Conotoxin Ca11a"
FT                   /id="PRO_0000392151"
FT   DISULFID        46..60
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        53..65
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        59..72
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        64..79
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   80 AA;  8581 MW;  66C19C7BB6CB880F CRC64;
     MKLVLAIVVI LMLLSLSTGA EMSDNHASRS ATARRDRHLS PKAWPCGGVR ASCSRHDDCC
     GSLCCFGTST GCRVAVRPCW