ID   I3BB_CONCB              Reviewed;          76 AA.
AC   D2DGD4;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=Conotoxin Ca11b {ECO:0000303|PubMed:19428762};
DE   AltName: Full=Ca-24 {ECO:0000303|PubMed:30917600};
DE   AltName: Full=Ca11.2 {ECO:0000312|EMBL:ACU30041.1};
DE   Flags: Precursor;
OS   Conus caracteristicus (Characteristic cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 43-76, SUBCELLULAR
RP   LOCATION, AND MASS SPECTROMETRY.
RX   PubMed=19428762; DOI=10.1016/j.peptides.2009.01.012;
RA   Yuan D.D., Liu L., Shao X.X., Peng C., Chi C.W., Guo Z.Y.;
RT   "New conotoxins define the novel I3-superfamily.";
RL   Peptides 30:861-865(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=30917600; DOI=10.3390/md17030193;
RA   Yao G., Peng C., Zhu Y., Fan C., Jiang H., Chen J., Cao Y., Shi Q.;
RT   "High-throughput identification and analysis of novel conotoxins from three
RT   vermivorous cone snails by transcriptome sequencing.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19428762}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:19428762}.
CC   -!- DOMAIN: The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3504.3; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:19428762};
CC   -!- SIMILARITY: Belongs to the conotoxin I3 superfamily. {ECO:0000305}.
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DR   EMBL; FJ531695; ACU30041.1; -; mRNA.
DR   AlphaFoldDB; D2DGD4; -.
DR   SMR; D2DGD4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   PROSITE; PS60019; I_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..42
FT                   /evidence="ECO:0000269|PubMed:19428762"
FT                   /id="PRO_0000392152"
FT   PEPTIDE         43..76
FT                   /note="Conotoxin Ca11b"
FT                   /id="PRO_0000392153"
FT   DISULFID        46..60
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        53..65
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        59..69
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
FT   DISULFID        64..76
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z094"
SQ   SEQUENCE   76 AA;  7975 MW;  59889A45C148430E CRC64;
     MKLVLAIVVI LMLLSLSTGA EMSDNHASMS ANALRDRLLG PKALLCGGTH ARCNRDNDCC
     GSLCCFGTCI SAFVPC