ID   I4E3B_XENLA             Reviewed;         218 AA.
AC   Q6NU27;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Eukaryotic translation initiation factor 4E type 3-B;
DE            Short=eIF-4E type 3-B;
DE            Short=eIF-4E3-B;
DE            Short=eIF4E type 3-B;
DE            Short=eIF4E-3-B;
GN   Name=eif4e3-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA
CC       cap during an early step in the initiation of protein synthesis.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of which
CC       varies with external and internal environmental conditions. It is
CC       composed of at least eIF4A, eIF4E and eIF4G (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.
CC       {ECO:0000305}.
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DR   EMBL; BC068775; AAH68775.1; -; mRNA.
DR   RefSeq; NP_001084675.1; NM_001091206.1.
DR   AlphaFoldDB; Q6NU27; -.
DR   SMR; Q6NU27; -.
DR   DNASU; 414635; -.
DR   GeneID; 414635; -.
DR   KEGG; xla:414635; -.
DR   CTD; 414635; -.
DR   Xenbase; XB-GENE-992076; eif4e3.L.
DR   OrthoDB; 1394271at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 414635; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005845; C:mRNA cap binding complex; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.760.10; -; 1.
DR   InterPro; IPR023398; TIF_eIF4e-like.
DR   InterPro; IPR001040; TIF_eIF_4E.
DR   PANTHER; PTHR11960; PTHR11960; 1.
DR   Pfam; PF01652; IF4E; 1.
DR   SUPFAM; SSF55418; SSF55418; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..218
FT                   /note="Eukaryotic translation initiation factor 4E type 3-
FT                   B"
FT                   /id="PRO_0000287701"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         109..110
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT                   /ligand_part_id="ChEBI:CHEBI:74429"
FT                   /ligand_part_note="m7GTP residue in mRNA cap"
FT                   /evidence="ECO:0000250"
FT   BINDING         163..168
FT                   /ligand="mRNA"
FT                   /ligand_id="ChEBI:CHEBI:33699"
FT                   /ligand_part="N(7)-methylguanosine 5'-triphosphate group"
FT                   /ligand_part_id="ChEBI:CHEBI:74429"
FT                   /ligand_part_note="m7GTP residue in mRNA cap"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   218 AA;  24901 MW;  0A4E99BBEE240259 CRC64;
     MALPVAPADR RLQPEPDEQV HLNHRELGEL DLPQEPDTEG IPLNSPWTFW LDRSLPGTTA
     AECESNLKKI YTVHTIQSFW SVYNNIPLVS NLPLRWSYHL MRGERKPLWE EESNAKGGVW
     KMKVPKEASS LVWKELLLAT IGEQFTDHCS PEDEVIGVSV SVRDREDVVQ VWNGNASVVG
     EAKVLEKIYE LLPNTSFKAV FYKPHEEHHA FEGGRSRH