APA_MYCLE
ID APA_MYCLE Reviewed; 287 AA.
AC P46842; O32905; Q9R5V6;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Alanine and proline-rich secreted protein Apa;
DE AltName: Full=Antigen 43L;
DE AltName: Full=FAP-L;
DE AltName: Full=Fibronectin attachment protein;
DE Flags: Precursor;
GN Name=apa; Synonyms=modD; OrderedLocusNames=ML2055; ORFNames=MLCB1788.01c;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8262636; DOI=10.1128/iai.62.1.252-258.1994;
RA Wieles B., van Agterveld M., Janson A., Clark-Curtiss J.E.,
RA Rinke de Wit T.F., Harboe M., Thole J.;
RT "Characterization of a Mycobacterium leprae antigen related to the secreted
RT Mycobacterium tuberculosis protein MPT32.";
RL Infect. Immun. 62:252-258(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7790081; DOI=10.1128/iai.63.7.2652-2657.1995;
RA Schorey J.S., Li Q., McCourt D.W., Bong-Mastek M., Clark-Curtiss J.E.,
RA Ratliff T.L., Brown E.J.;
RT "A Mycobacterium leprae gene encoding a fibronectin binding protein is used
RT for efficient invasion of epithelial cells and Schwann cells.";
RL Infect. Immun. 63:2652-2657(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the Apa family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X76501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL583924; CAC31010.1; -; Genomic_DNA.
DR EMBL; AL008609; CAA15433.1; -; Genomic_DNA.
DR PIR; B87166; B87166.
DR PIR; T44744; T44744.
DR RefSeq; NP_302372.1; NC_002677.1.
DR RefSeq; WP_010908692.1; NC_002677.1.
DR AlphaFoldDB; P46842; -.
DR SMR; P46842; -.
DR STRING; 272631.ML2055; -.
DR EnsemblBacteria; CAC31010; CAC31010; CAC31010.
DR KEGG; mle:ML2055; -.
DR PATRIC; fig|272631.5.peg.3867; -.
DR Leproma; ML2055; -.
DR eggNOG; ENOG50346X3; Bacteria.
DR HOGENOM; CLU_064064_0_0_11; -.
DR OMA; WVESDAS; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050840; F:extracellular matrix binding; IEA:InterPro.
DR InterPro; IPR010801; FAP.
DR Pfam; PF07174; FAP; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..39
FT /evidence="ECO:0000255"
FT CHAIN 40..287
FT /note="Alanine and proline-rich secreted protein Apa"
FT /id="PRO_0000020744"
FT REPEAT 76..79
FT /note="1"
FT REPEAT 83..86
FT /note="2"
FT REPEAT 93..96
FT /note="3"
FT REGION 40..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..96
FT /note="3 X 4 AA repeats of D-P-N-A"
FT CONFLICT 33..34
FT /note="LP -> FR (in Ref. 1; X76501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 287 AA; 29559 MW; 7FC860A8B3026CFB CRC64;
MNQVDLDSTH RKGLWAILAI AVVASASAFT MPLPAAANAD PAPLPPSTAT AAPSPAQEII
TPLPGAPVSS EAQPGDPNAP SLDPNAPYPL AVDPNAGRIT NAVGGFSFVL PAGWVESEAS
HLDYGSVLLS KAIEQPPVLG QPTVVATDTR IVLGRLDQKL YASAEADNIK AAVRLGSDMG
EFYLPYPGTR INQETIPLHA NGIAGSASYY EVKFSDPNKP IGQICTSVVG SPAASTPDVG
PSQRWFVVWL GTSNNPVDKG AAKELAESIR SEMAPIPASV SAPAPVG