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APA_MYCLE
ID   APA_MYCLE               Reviewed;         287 AA.
AC   P46842; O32905; Q9R5V6;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Alanine and proline-rich secreted protein Apa;
DE   AltName: Full=Antigen 43L;
DE   AltName: Full=FAP-L;
DE   AltName: Full=Fibronectin attachment protein;
DE   Flags: Precursor;
GN   Name=apa; Synonyms=modD; OrderedLocusNames=ML2055; ORFNames=MLCB1788.01c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8262636; DOI=10.1128/iai.62.1.252-258.1994;
RA   Wieles B., van Agterveld M., Janson A., Clark-Curtiss J.E.,
RA   Rinke de Wit T.F., Harboe M., Thole J.;
RT   "Characterization of a Mycobacterium leprae antigen related to the secreted
RT   Mycobacterium tuberculosis protein MPT32.";
RL   Infect. Immun. 62:252-258(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7790081; DOI=10.1128/iai.63.7.2652-2657.1995;
RA   Schorey J.S., Li Q., McCourt D.W., Bong-Mastek M., Clark-Curtiss J.E.,
RA   Ratliff T.L., Brown E.J.;
RT   "A Mycobacterium leprae gene encoding a fibronectin binding protein is used
RT   for efficient invasion of epithelial cells and Schwann cells.";
RL   Infect. Immun. 63:2652-2657(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the Apa family. {ECO:0000305}.
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DR   EMBL; X76501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL583924; CAC31010.1; -; Genomic_DNA.
DR   EMBL; AL008609; CAA15433.1; -; Genomic_DNA.
DR   PIR; B87166; B87166.
DR   PIR; T44744; T44744.
DR   RefSeq; NP_302372.1; NC_002677.1.
DR   RefSeq; WP_010908692.1; NC_002677.1.
DR   AlphaFoldDB; P46842; -.
DR   SMR; P46842; -.
DR   STRING; 272631.ML2055; -.
DR   EnsemblBacteria; CAC31010; CAC31010; CAC31010.
DR   KEGG; mle:ML2055; -.
DR   PATRIC; fig|272631.5.peg.3867; -.
DR   Leproma; ML2055; -.
DR   eggNOG; ENOG50346X3; Bacteria.
DR   HOGENOM; CLU_064064_0_0_11; -.
DR   OMA; WVESDAS; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050840; F:extracellular matrix binding; IEA:InterPro.
DR   InterPro; IPR010801; FAP.
DR   Pfam; PF07174; FAP; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..39
FT                   /evidence="ECO:0000255"
FT   CHAIN           40..287
FT                   /note="Alanine and proline-rich secreted protein Apa"
FT                   /id="PRO_0000020744"
FT   REPEAT          76..79
FT                   /note="1"
FT   REPEAT          83..86
FT                   /note="2"
FT   REPEAT          93..96
FT                   /note="3"
FT   REGION          40..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          76..96
FT                   /note="3 X 4 AA repeats of D-P-N-A"
FT   CONFLICT        33..34
FT                   /note="LP -> FR (in Ref. 1; X76501)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   287 AA;  29559 MW;  7FC860A8B3026CFB CRC64;
     MNQVDLDSTH RKGLWAILAI AVVASASAFT MPLPAAANAD PAPLPPSTAT AAPSPAQEII
     TPLPGAPVSS EAQPGDPNAP SLDPNAPYPL AVDPNAGRIT NAVGGFSFVL PAGWVESEAS
     HLDYGSVLLS KAIEQPPVLG QPTVVATDTR IVLGRLDQKL YASAEADNIK AAVRLGSDMG
     EFYLPYPGTR INQETIPLHA NGIAGSASYY EVKFSDPNKP IGQICTSVVG SPAASTPDVG
     PSQRWFVVWL GTSNNPVDKG AAKELAESIR SEMAPIPASV SAPAPVG
 
 
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