I5P1_CAEEL
ID I5P1_CAEEL Reviewed; 409 AA.
AC Q17848; Q8WRS7;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Probable type I inositol 1,4,5-trisphosphate 5-phosphatase;
DE Short=5PTase;
DE EC=3.1.3.56;
GN Name=ipp-5; ORFNames=C09B8.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-400.
RA Kohara Y., Motohashi T., Tabara H., Watanabe H., Sugimoto A., Sano M.,
RA Miyata A., Nishigaki A., Bui Y.K., Sternberg P.W.;
RT "Expression map of C. elegans genome.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol
CC 1,4-bisphosphate + phosphate; Xref=Rhea:RHEA:19797,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58282,
CC ChEBI:CHEBI:203600; EC=3.1.3.56;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-
CC inositol 1,3,4-trisphosphate + phosphate; Xref=Rhea:RHEA:11392,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57895,
CC ChEBI:CHEBI:58414; EC=3.1.3.56;
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type I family. {ECO:0000305}.
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DR EMBL; FO080450; CCD63797.1; -; Genomic_DNA.
DR EMBL; AF411588; AAL72637.1; -; mRNA.
DR PIR; T15465; T15465.
DR RefSeq; NP_509008.2; NM_076607.6.
DR AlphaFoldDB; Q17848; -.
DR BioGRID; 45803; 14.
DR STRING; 6239.C09B8.1; -.
DR iPTMnet; Q17848; -.
DR EPD; Q17848; -.
DR PaxDb; Q17848; -.
DR PeptideAtlas; Q17848; -.
DR PRIDE; Q17848; -.
DR EnsemblMetazoa; C09B8.1a.1; C09B8.1a.1; WBGene00002146.
DR GeneID; 180871; -.
DR KEGG; cel:CELE_C09B8.1; -.
DR UCSC; C09B8.1; c. elegans.
DR CTD; 180871; -.
DR WormBase; C09B8.1a; CE30857; WBGene00002146; ipp-5.
DR eggNOG; KOG1976; Eukaryota.
DR GeneTree; ENSGT00390000015226; -.
DR HOGENOM; CLU_057709_1_0_1; -.
DR InParanoid; Q17848; -.
DR OMA; GDHKPVM; -.
DR OrthoDB; 642737at2759; -.
DR PhylomeDB; Q17848; -.
DR Reactome; R-CEL-1855183; Synthesis of IP2, IP, and Ins in the cytosol.
DR PRO; PR:Q17848; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002146; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; Q17848; baseline and differential.
DR GO; GO:0052745; F:inositol phosphate phosphatase activity; ISS:WormBase.
DR GO; GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IBA:GO_Central.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IGI:WormBase.
DR GO; GO:0048815; P:hermaphrodite genitalia morphogenesis; IGI:UniProtKB.
DR GO; GO:0046855; P:inositol phosphate dephosphorylation; IBA:GO_Central.
DR GO; GO:0048016; P:inositol phosphate-mediated signaling; IGI:WormBase.
DR GO; GO:0030728; P:ovulation; IMP:WormBase.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:WormBase.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR039737; INPP5A.
DR InterPro; IPR000300; IPPc.
DR PANTHER; PTHR12997; PTHR12997; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Reference proteome.
FT CHAIN 1..409
FT /note="Probable type I inositol 1,4,5-trisphosphate 5-
FT phosphatase"
FT /id="PRO_0000209720"
SQ SEQUENCE 409 AA; 47602 MW; 1A3CC044F00F9443 CRC64;
MVQYLLITAN VGSLFEPDAR LHTSWIKTVA DQVESVDPSF FVIHLQETGG KKFTECSQQV
PIIINRLSTA LPKFDLLRAY VDIDYEAIEY TALGALCFIK RSLWSNVSQF NFHTKKYEQL
TSPKEVVTHG LENYPYVVKH KFPKDFWPSI KWGRKGYMQT RWKIENKVFD FVNAHLFHDE
SNLALIHENP QLYSQNRKRA LDFVLAELSS KENGCTPLLF VFGDLNFRLD SRSFLNRLTE
RTAQHPVADQ EQMGSLADGL QASAANLQVI THPSENLRRT VSAIEFRRES DSDDSQNSCV
LRIEKKKFDY FNHKKLLDDW RSYRDDDKET ENFQSMFEMH INFPPTYPWS EDPENSETLM
KTRAPAWCDR VLMNKNAYSL VEEGEPQYRS FGMETCTGDH KPVMLTFNI
