APA_MYCTO
ID APA_MYCTO Reviewed; 325 AA.
AC P9WIR6; L0T9G7; O08062; Q50906;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 27.
DE RecName: Full=Alanine and proline-rich secreted protein Apa;
DE AltName: Full=45 kDa glycoprotein;
DE AltName: Full=45/47 kDa antigen;
DE AltName: Full=Antigen MPT-32;
DE AltName: Full=FAP-B;
DE AltName: Full=Fibronectin attachment protein;
DE AltName: Full=Immunogenic protein MPT32;
DE Flags: Precursor;
GN Name=apa; Synonyms=modD; OrderedLocusNames=MT1908;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Apa family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000516; AAK46179.1; -; Genomic_DNA.
DR PIR; D70666; D70666.
DR RefSeq; WP_003409337.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WIR6; -.
DR SMR; P9WIR6; -.
DR EnsemblBacteria; AAK46179; AAK46179; MT1908.
DR GeneID; 45425833; -.
DR KEGG; mtc:MT1908; -.
DR PATRIC; fig|83331.31.peg.2052; -.
DR HOGENOM; CLU_064064_0_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050840; F:extracellular matrix binding; IEA:InterPro.
DR InterPro; IPR010801; FAP.
DR Pfam; PF07174; FAP; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Repeat; Secreted; Signal.
FT SIGNAL 1..39
FT /evidence="ECO:0000250"
FT CHAIN 40..325
FT /note="Alanine and proline-rich secreted protein Apa"
FT /id="PRO_0000427958"
FT REPEAT 85..88
FT /note="1"
FT REPEAT 94..97
FT /note="2"
FT REPEAT 104..107
FT /note="3"
FT REGION 38..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..107
FT /note="3 X 4 AA approximate repeats of [DA]-P-N-A"
FT REGION 286..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..107
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 49
FT /note="O-linked (Man...) threonine"
FT /evidence="ECO:0000250"
FT CARBOHYD 57
FT /note="O-linked (Man...) threonine"
FT /evidence="ECO:0000250"
FT CARBOHYD 66
FT /note="O-linked (Man) threonine"
FT /evidence="ECO:0000250"
FT CARBOHYD 316
FT /note="O-linked (Man...) threonine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 325 AA; 32687 MW; D3419CA5547D91E9 CRC64;
MHQVDPNLTR RKGRLAALAI AAMASASLVT VAVPATANAD PEPAPPVPTT AASPPSTAAA
PPAPATPVAP PPPAAANTPN AQPGDPNAAP PPADPNAPPP PVIAPNAPQP VRIDNPVGGF
SFALPAGWVE SDAAHLDYGS ALLSKTTGDP PFPGQPPPVA NDTRIVLGRL DQKLYASAEA
TDSKAAARLG SDMGEFYMPY PGTRINQETV SLDANGVSGS ASYYEVKFSD PSKPNGQIWT
GVIGSPAANA PDAGPPQRWF VVWLGTANNP VDKGAAKALA ESIRPLVAPP PAPAPAPAEP
APAPAPAGEV APTPTTPTPQ RTLPA
