ID   I5_VARV                 Reviewed;          79 AA.
AC   P0DSS2; P33001;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Protein I5;
GN   ORFNames=I5L, K5L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: Envelope protein.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Multi-pass
CC       membrane protein. Note=Probably localizes to the membrane of mature
CC       virions (MV). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the Chordopoxvirinae I5 family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60807.1; -; Genomic_DNA.
DR   PIR; T28497; T28497.
DR   RefSeq; NP_042103.1; NC_001611.1.
DR   GeneID; 1486460; -.
DR   KEGG; vg:1486460; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006803; Poxvirus_I5.
DR   Pfam; PF04713; Pox_I5; 1.
DR   PIRSF; PIRSF003768; VAC_I5L; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Membrane; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Virion.
FT   CHAIN           1..79
FT                   /note="Protein I5"
FT                   /id="PRO_0000448201"
FT   TOPO_DOM        1..3
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..47
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..79
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   79 AA;  8778 MW;  AD4E703B701B5C86 CRC64;
     MADAITVLTA IGITVLMLLM VISGTAMIVK ELNPNDIFTM QSLKFNRAVT IFKYIGLFIY
     IPGTIILYAT YIKSLLMKS