ID   I6_VAR67                Reviewed;         382 AA.
AC   P0DOL9; P33002;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 8.
DE   RecName: Full=Telomere-binding protein I6;
GN   ORFNames=I6L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383392; DOI=10.1016/0168-1702(93)90110-9;
RA   Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S.,
RA   Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V.,
RA   Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G.,
RA   Sandakhchiev L.S.;
RT   "Nucleotide sequence analysis of variola virus HindIII M, L, I genome
RT   fragments.";
RL   Virus Res. 27:25-35(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Binds to the hairpin form of the viral telomeric sequence.
CC       Might direct genome encapsidation into the virus particle (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Present in the virus
CC       core. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I6 family. {ECO:0000305}.
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DR   EMBL; X67119; CAA47560.1; -; Genomic_DNA.
DR   EMBL; X69198; CAA49001.1; -; Genomic_DNA.
DR   PIR; S33075; S33075.
DR   RefSeq; NP_042104.1; NC_001611.1.
DR   GeneID; 1486461; -.
DR   KEGG; vg:1486461; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR007674; Poxvirus_36kDa_major_membrane.
DR   InterPro; IPR022219; Poxvirus_I6_C.
DR   Pfam; PF12562; DUF3746; 1.
DR   Pfam; PF04595; Pox_I6; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Virion.
FT   CHAIN           1..382
FT                   /note="Telomere-binding protein I6"
FT                   /id="PRO_0000099580"
SQ   SEQUENCE   382 AA;  43500 MW;  A1C63FE56CCA7D2D CRC64;
     MNNFVKQVAS KSLKPTKKLS PSDEVISLNE CIISFNLDNF YYCNDGLFTK PINTPEDVLK
     SLLIMESFAY EKMIIKGLIK ILISRAYIND IYFTPFGWLT GIDDDPETHV VIKIIFNSSL
     ISIKSQVIEY LKPYNVNNLS VLTTEKELSI NTFNVPDSIP MSIISFFPFD TDFILVILFF
     GVYNDSYCGI SYISPKERLP YIIEILKPLM SEINMLSDEI GRTSSIRIFN STSVKKFPTN
     TLTSICEIVY SFDESSFPTP KTFTPLNASP YIPKKIVSLL DLPSNVEIKA ISRGGVDFIT
     HINNKRLNTI LVIAKDNFLK NSTFSGTFIK ENIIWKGIYT YRIIKSSFPV PTIKSVTNKK
     KICKKHCFVN SQYTTRTLSH IL